Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

E.F. Hoek-van den Hil; J. Keijer; A. Bunschoten; Jacques Vervoort; B. Stankova; M. Bekkenkamp-Grovestein; L. Herreman; D.P. Venema; P.C.H. Hollman; E. Tvrzicka; I. Rietjens; E.M. van Schothorst

doi:10.1371/journal.pone.0051588

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

E.F. Hoek-van den Hil
, J. Keijer
, A. Bunschoten
, Jacques Vervoort
, B. Stankova
, M. Bekkenkamp-Grovestein
, L. Herreman
, D.P. Venema
, P.C.H. Hollman
, E. Tvrzicka
, I. Rietjens
, E.M. van Schothorst

Research output: Contribution to journal › Article › Academic › peer-review

86 Citations (Scopus)

Abstract

Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and 1H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14% (p

Original language	English
Article number	e51588
Number of pages	10
Journal	PLoS ONE
Volume	8
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0051588
Publication status	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

fatty-acid oxidation
cytochrome-p450 reductase
liver-disease
receptor car
metabolism
dietary
rat
flavonoids
risk
hydroxylases

Access to Document

10.1371/journal.pone.0051588

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice [Mus Musculus]
van Schothorst, E. M. (Creator), Keijer, J. (Creator), Bunschoten, J. E. (Creator), van den Hil, E. F. (Creator), Rietjens, I. M. C. M. (Creator) & Hollman, P. C. H. (Creator), Wageningen UR, 5 Feb 2013
http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE39140
Dataset

VLAG AIO Risk-benefit flavonoïden (KB-15-001-017, KB-05-001-033)
Hollman, P. (Project Leader)
1/01/10 → 31/12/14
Project: LVVN project

Cite this

Hoek-van den Hil, E. F., Keijer, J., Bunschoten, A., Vervoort, J., Stankova, B., Bekkenkamp-Grovestein, M., Herreman, L., Venema, D. P., Hollman, P. C. H., Tvrzicka, E., Rietjens, I., & van Schothorst, E. M. (2013). Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice. PLoS ONE, 8(1), Article e51588. https://doi.org/10.1371/journal.pone.0051588

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title = "Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice",

abstract = "Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33\% (w/w) quercetin for 12 weeks. Gas chromatography and 1H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14\% (p",

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AU - Hoek-van den Hil, E.F.

AU - Keijer, J.

AU - Bunschoten, A.

AU - Vervoort, Jacques

AU - Stankova, B.

AU - Bekkenkamp-Grovestein, M.

AU - Herreman, L.

AU - Venema, D.P.

AU - Hollman, P.C.H.

AU - Tvrzicka, E.

AU - Rietjens, I.

AU - van Schothorst, E.M.

PY - 2013

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AB - Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and 1H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14% (p

KW - fatty-acid oxidation

KW - cytochrome-p450 reductase

KW - liver-disease

KW - receptor car

KW - metabolism

KW - dietary

KW - rat

KW - flavonoids

KW - risk

KW - hydroxylases

U2 - 10.1371/journal.pone.0051588

DO - 10.1371/journal.pone.0051588

M3 - Article

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VL - 8

JO - PLoS ONE

JF - PLoS ONE

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ER -

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

Abstract

UN SDGs

Keywords

Access to Document

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Datasets

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice [Mus Musculus]

Projects

VLAG AIO Risk-benefit flavonoïden (KB-15-001-017, KB-05-001-033)

Cite this