Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

E.F. Hoek-van den Hil, J. Keijer, A. Bunschoten, Jacques Vervoort, B. Stankova, M. Bekkenkamp-Grovestein, L. Herreman, D.P. Venema, P.C.H. Hollman, E. Tvrzicka, I. Rietjens, E.M. van Schothorst

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and 1H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14% (p
LanguageEnglish
Article numbere51588
Number of pages10
JournalPLoS ONE
Volume8
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Quercetin
blood lipids
quercetin
oxidation
Lipids
Oxidation
liver
Liver
mice
lipids
Serum
Tissue Array Analysis
High Fat Diet
high fat diet
Microarrays
Nutrition
Energy Intake
Lipid Metabolism
lipid metabolism
Gas chromatography

Keywords

  • fatty-acid oxidation
  • cytochrome-p450 reductase
  • liver-disease
  • receptor car
  • metabolism
  • dietary
  • rat
  • flavonoids
  • risk
  • hydroxylases

Cite this

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title = "Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice",
abstract = "Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33{\%} (w/w) quercetin for 12 weeks. Gas chromatography and 1H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14{\%} (p",
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Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice. / Hoek-van den Hil, E.F.; Keijer, J.; Bunschoten, A.; Vervoort, Jacques; Stankova, B.; Bekkenkamp-Grovestein, M.; Herreman, L.; Venema, D.P.; Hollman, P.C.H.; Tvrzicka, E.; Rietjens, I.; van Schothorst, E.M.

In: PLoS ONE, Vol. 8, No. 1, e51588, 2013.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

AU - Hoek-van den Hil, E.F.

AU - Keijer, J.

AU - Bunschoten, A.

AU - Vervoort, Jacques

AU - Stankova, B.

AU - Bekkenkamp-Grovestein, M.

AU - Herreman, L.

AU - Venema, D.P.

AU - Hollman, P.C.H.

AU - Tvrzicka, E.

AU - Rietjens, I.

AU - van Schothorst, E.M.

PY - 2013

Y1 - 2013

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AB - Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and 1H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14% (p

KW - fatty-acid oxidation

KW - cytochrome-p450 reductase

KW - liver-disease

KW - receptor car

KW - metabolism

KW - dietary

KW - rat

KW - flavonoids

KW - risk

KW - hydroxylases

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