Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

E.F. Hoek-van den Hil, J. Keijer, A. Bunschoten, Jacques Vervoort, B. Stankova, M. Bekkenkamp-Grovestein, L. Herreman, D.P. Venema, P.C.H. Hollman, E. Tvrzicka, I. Rietjens, E.M. van Schothorst

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Abstract

Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and 1H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14% (p
Original languageEnglish
Article numbere51588
Number of pages10
JournalPLoS ONE
Volume8
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • fatty-acid oxidation
  • cytochrome-p450 reductase
  • liver-disease
  • receptor car
  • metabolism
  • dietary
  • rat
  • flavonoids
  • risk
  • hydroxylases

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