Quantitative trait loci associated with pre-weaning growth in South African Angora goats

C. Visser, E. van Marle-Koster, M.A. Snyman, H. Bovenhuis, R.P.M.A. Crooijmans

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

This study aimed to identify chromosomal regions associated with genetic variation in pre-weaning growth traits in Angora goats. A genome-wide scan was performed by genotyping 1042 offspring from 12 half-sib families using 88 microsatellite caprine markers covering 1368cM. Phenotypes were recorded at birth (BW) and weaning (WW) and analysed using GridQTL software. A total of six putative QTL were detected on six different chromosomes, all at chromosome-wide significance level. Four QTL were identified for BW on CHI 4, 8, 17 and 27 and two QTL for WW on CHI 16 and 19. QTL effects ranged from -0.32 to 0.25 in units of residual standard deviation in different families. Some of these QTL correspond to chromosomes where QTL associated with growth have been identified in other species. These chromosomal segments hold potential to influence weight gain in young goats.
Original languageEnglish
Pages (from-to)15-20
JournalSmall Ruminant Research
Volume112
Issue number1-3
DOIs
Publication statusPublished - 2013

Fingerprint

Angora (goat breed)
Quantitative Trait Loci
Weaning
Goats
quantitative trait loci
weaning
Chromosomes
Growth
chromosomes
Microsatellite Repeats
Weight Gain
Software
goats
Parturition
Genome
Phenotype
growth traits
genotyping
weight gain
microsatellite repeats

Keywords

  • genome-wide association
  • microsatellite markers
  • genetic-parameters
  • parentage verification
  • conformation traits
  • carcass composition
  • wool production
  • fleece traits
  • merino sheep
  • beef-cattle

Cite this

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title = "Quantitative trait loci associated with pre-weaning growth in South African Angora goats",
abstract = "This study aimed to identify chromosomal regions associated with genetic variation in pre-weaning growth traits in Angora goats. A genome-wide scan was performed by genotyping 1042 offspring from 12 half-sib families using 88 microsatellite caprine markers covering 1368cM. Phenotypes were recorded at birth (BW) and weaning (WW) and analysed using GridQTL software. A total of six putative QTL were detected on six different chromosomes, all at chromosome-wide significance level. Four QTL were identified for BW on CHI 4, 8, 17 and 27 and two QTL for WW on CHI 16 and 19. QTL effects ranged from -0.32 to 0.25 in units of residual standard deviation in different families. Some of these QTL correspond to chromosomes where QTL associated with growth have been identified in other species. These chromosomal segments hold potential to influence weight gain in young goats.",
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Quantitative trait loci associated with pre-weaning growth in South African Angora goats. / Visser, C.; van Marle-Koster, E.; Snyman, M.A.; Bovenhuis, H.; Crooijmans, R.P.M.A.

In: Small Ruminant Research, Vol. 112, No. 1-3, 2013, p. 15-20.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Quantitative trait loci associated with pre-weaning growth in South African Angora goats

AU - Visser, C.

AU - van Marle-Koster, E.

AU - Snyman, M.A.

AU - Bovenhuis, H.

AU - Crooijmans, R.P.M.A.

PY - 2013

Y1 - 2013

N2 - This study aimed to identify chromosomal regions associated with genetic variation in pre-weaning growth traits in Angora goats. A genome-wide scan was performed by genotyping 1042 offspring from 12 half-sib families using 88 microsatellite caprine markers covering 1368cM. Phenotypes were recorded at birth (BW) and weaning (WW) and analysed using GridQTL software. A total of six putative QTL were detected on six different chromosomes, all at chromosome-wide significance level. Four QTL were identified for BW on CHI 4, 8, 17 and 27 and two QTL for WW on CHI 16 and 19. QTL effects ranged from -0.32 to 0.25 in units of residual standard deviation in different families. Some of these QTL correspond to chromosomes where QTL associated with growth have been identified in other species. These chromosomal segments hold potential to influence weight gain in young goats.

AB - This study aimed to identify chromosomal regions associated with genetic variation in pre-weaning growth traits in Angora goats. A genome-wide scan was performed by genotyping 1042 offspring from 12 half-sib families using 88 microsatellite caprine markers covering 1368cM. Phenotypes were recorded at birth (BW) and weaning (WW) and analysed using GridQTL software. A total of six putative QTL were detected on six different chromosomes, all at chromosome-wide significance level. Four QTL were identified for BW on CHI 4, 8, 17 and 27 and two QTL for WW on CHI 16 and 19. QTL effects ranged from -0.32 to 0.25 in units of residual standard deviation in different families. Some of these QTL correspond to chromosomes where QTL associated with growth have been identified in other species. These chromosomal segments hold potential to influence weight gain in young goats.

KW - genome-wide association

KW - microsatellite markers

KW - genetic-parameters

KW - parentage verification

KW - conformation traits

KW - carcass composition

KW - wool production

KW - fleece traits

KW - merino sheep

KW - beef-cattle

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DO - 10.1016/j.smallrumres.2012.11.035

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SP - 15

EP - 20

JO - Small Ruminant Research

JF - Small Ruminant Research

SN - 0921-4488

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ER -