Quantitative genetics in the age of omics

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Abstract

The use of natural variation in the genetic dissection of quantitative traits has a long-standing tradition. Recent advances in high-throughput technologies for the quantification of biological molecules have shifted the focus in quantitative genetics from single traits to comprehensive large-scale analyses. So-called omic technologies now enable geneticists to take a look in the black box that translates genetic information into biological function. These processes include transcriptional and (post) translational regulation as well as metabolic signaling pathways. The progress made in analytical and statistical techniques now allows the construction of regulatory networks that integrate the different levels of the biological information flow from gene-to-function
Original languageEnglish
Pages (from-to)123-128
JournalCurrent Opinion in Plant Biology
Volume11
DOIs
Publication statusPublished - 2008

Keywords

  • single-feature polymorphism
  • arabidopsis-thaliana
  • natural variation
  • transcriptional regulation
  • trait loci
  • linkage disequilibrium
  • secondary metabolism
  • functional genomics
  • regulatory networks
  • mass-spectrometry

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