Quantitative assessment of antimicrobial resistance in livestock during the course of a Nationwide antimicrobial use reduction in the Nethterlands

Alejandro Dorado-García, D.J. Mevius, José J.H. Jacobs, I.M. van Geijlswijk, J.W. Mouton, J.A. Wagenaar, Dick Heederik

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Abstract

Objectives To quantify associations between antimicrobial use and acquired resistance in indicator Escherichia coli over a period of time which involved sector-wide antimicrobial use reductions in broilers and pigs (years 2004–14), veal calves (2007–14) and dairy cattle (2005–14). Prevalence estimates of resistance were predicted for a hypothetical further decrease in antimicrobial use.

Methods Data reported annually for the resistance surveillance programme in the Netherlands were retrieved. Two multivariate random-effects logistic models per animal sector were used to relate total and class-specific antimicrobial use (as defined daily dosages per animal per year, DDDA/Y) with the probability of E. coli resistance to a panel of 10 antimicrobial agents.

Results Positive dose–response relationships (ORs) were obtained from all models. Specific resistance phenotypes were more often associated with total antimicrobial use than with class-specific use. The most robust associations were found in pigs and veal calves. Resistance to historically widely used antimicrobials (e.g. penicillins, tetracyclines) was, in relative terms, less influenced by drug use changes over time than resistance to newer or less prescribed antimicrobials (e.g. third-/fourth-generation cephalosporins, fluoroquinolones). In pigs and veal calves, prevalence estimates for the most common resistance phenotypes were projected to decline ∼5%–25% during 2014–16 if total antimicrobial use reduction reached 80%; projections for poultry and dairy cows were more modest.

Conclusions Epidemiological evidence indicated that drug use history and co-selection of resistance are key elements for perpetuation of resistance. Data suggest that recent Dutch policies aimed at reducing total use of antimicrobials have decreased E. coli resistance in the pig and veal calf production sectors while the impact on the dairy cattle and poultry sectors is less clear.
Original languageEnglish
Pages (from-to)3607-3619
JournalJournal of Antimicrobial Chemotherapy
Volume71
Issue number12
DOIs
Publication statusPublished - 2016

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Livestock
Swine
Poultry
Escherichia coli
Phenotype
Tetracyclines
Fluoroquinolones
Cephalosporins
Anti-Infective Agents
Penicillins
Pharmaceutical Preparations
Netherlands
Logistic Models

Cite this

Dorado-García, Alejandro ; Mevius, D.J. ; Jacobs, José J.H. ; van Geijlswijk, I.M. ; Mouton, J.W. ; Wagenaar, J.A. ; Heederik, Dick. / Quantitative assessment of antimicrobial resistance in livestock during the course of a Nationwide antimicrobial use reduction in the Nethterlands. In: Journal of Antimicrobial Chemotherapy. 2016 ; Vol. 71, No. 12. pp. 3607-3619.
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title = "Quantitative assessment of antimicrobial resistance in livestock during the course of a Nationwide antimicrobial use reduction in the Nethterlands",
abstract = "Objectives To quantify associations between antimicrobial use and acquired resistance in indicator Escherichia coli over a period of time which involved sector-wide antimicrobial use reductions in broilers and pigs (years 2004–14), veal calves (2007–14) and dairy cattle (2005–14). Prevalence estimates of resistance were predicted for a hypothetical further decrease in antimicrobial use. Methods Data reported annually for the resistance surveillance programme in the Netherlands were retrieved. Two multivariate random-effects logistic models per animal sector were used to relate total and class-specific antimicrobial use (as defined daily dosages per animal per year, DDDA/Y) with the probability of E. coli resistance to a panel of 10 antimicrobial agents. Results Positive dose–response relationships (ORs) were obtained from all models. Specific resistance phenotypes were more often associated with total antimicrobial use than with class-specific use. The most robust associations were found in pigs and veal calves. Resistance to historically widely used antimicrobials (e.g. penicillins, tetracyclines) was, in relative terms, less influenced by drug use changes over time than resistance to newer or less prescribed antimicrobials (e.g. third-/fourth-generation cephalosporins, fluoroquinolones). In pigs and veal calves, prevalence estimates for the most common resistance phenotypes were projected to decline ∼5{\%}–25{\%} during 2014–16 if total antimicrobial use reduction reached 80{\%}; projections for poultry and dairy cows were more modest. Conclusions Epidemiological evidence indicated that drug use history and co-selection of resistance are key elements for perpetuation of resistance. Data suggest that recent Dutch policies aimed at reducing total use of antimicrobials have decreased E. coli resistance in the pig and veal calf production sectors while the impact on the dairy cattle and poultry sectors is less clear.",
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Quantitative assessment of antimicrobial resistance in livestock during the course of a Nationwide antimicrobial use reduction in the Nethterlands. / Dorado-García, Alejandro; Mevius, D.J.; Jacobs, José J.H.; van Geijlswijk, I.M.; Mouton, J.W.; Wagenaar, J.A.; Heederik, Dick.

In: Journal of Antimicrobial Chemotherapy, Vol. 71, No. 12, 2016, p. 3607-3619.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Quantitative assessment of antimicrobial resistance in livestock during the course of a Nationwide antimicrobial use reduction in the Nethterlands

AU - Dorado-García, Alejandro

AU - Mevius, D.J.

AU - Jacobs, José J.H.

AU - van Geijlswijk, I.M.

AU - Mouton, J.W.

AU - Wagenaar, J.A.

AU - Heederik, Dick

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N2 - Objectives To quantify associations between antimicrobial use and acquired resistance in indicator Escherichia coli over a period of time which involved sector-wide antimicrobial use reductions in broilers and pigs (years 2004–14), veal calves (2007–14) and dairy cattle (2005–14). Prevalence estimates of resistance were predicted for a hypothetical further decrease in antimicrobial use. Methods Data reported annually for the resistance surveillance programme in the Netherlands were retrieved. Two multivariate random-effects logistic models per animal sector were used to relate total and class-specific antimicrobial use (as defined daily dosages per animal per year, DDDA/Y) with the probability of E. coli resistance to a panel of 10 antimicrobial agents. Results Positive dose–response relationships (ORs) were obtained from all models. Specific resistance phenotypes were more often associated with total antimicrobial use than with class-specific use. The most robust associations were found in pigs and veal calves. Resistance to historically widely used antimicrobials (e.g. penicillins, tetracyclines) was, in relative terms, less influenced by drug use changes over time than resistance to newer or less prescribed antimicrobials (e.g. third-/fourth-generation cephalosporins, fluoroquinolones). In pigs and veal calves, prevalence estimates for the most common resistance phenotypes were projected to decline ∼5%–25% during 2014–16 if total antimicrobial use reduction reached 80%; projections for poultry and dairy cows were more modest. Conclusions Epidemiological evidence indicated that drug use history and co-selection of resistance are key elements for perpetuation of resistance. Data suggest that recent Dutch policies aimed at reducing total use of antimicrobials have decreased E. coli resistance in the pig and veal calf production sectors while the impact on the dairy cattle and poultry sectors is less clear.

AB - Objectives To quantify associations between antimicrobial use and acquired resistance in indicator Escherichia coli over a period of time which involved sector-wide antimicrobial use reductions in broilers and pigs (years 2004–14), veal calves (2007–14) and dairy cattle (2005–14). Prevalence estimates of resistance were predicted for a hypothetical further decrease in antimicrobial use. Methods Data reported annually for the resistance surveillance programme in the Netherlands were retrieved. Two multivariate random-effects logistic models per animal sector were used to relate total and class-specific antimicrobial use (as defined daily dosages per animal per year, DDDA/Y) with the probability of E. coli resistance to a panel of 10 antimicrobial agents. Results Positive dose–response relationships (ORs) were obtained from all models. Specific resistance phenotypes were more often associated with total antimicrobial use than with class-specific use. The most robust associations were found in pigs and veal calves. Resistance to historically widely used antimicrobials (e.g. penicillins, tetracyclines) was, in relative terms, less influenced by drug use changes over time than resistance to newer or less prescribed antimicrobials (e.g. third-/fourth-generation cephalosporins, fluoroquinolones). In pigs and veal calves, prevalence estimates for the most common resistance phenotypes were projected to decline ∼5%–25% during 2014–16 if total antimicrobial use reduction reached 80%; projections for poultry and dairy cows were more modest. Conclusions Epidemiological evidence indicated that drug use history and co-selection of resistance are key elements for perpetuation of resistance. Data suggest that recent Dutch policies aimed at reducing total use of antimicrobials have decreased E. coli resistance in the pig and veal calf production sectors while the impact on the dairy cattle and poultry sectors is less clear.

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DO - 10.1093/jac/dkw308

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SP - 3607

EP - 3619

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

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