Pyrrolizidine alkaloids in food and phytomedicine

Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review

Dieter Schrenk*, Lan Gao, Ge Lin, Catherine Mahony, Patrick P.J. Mulder, Ad Peijnenburg, Stefan Pfuhler, Ivonne M.C.M. Rietjens, Lukas Rutz, Barbara Steinhoff, Anja These

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Among naturally occurring plant constituents, the 1,2-unsaturated pyrrolizidine alkaloids (in the following termed ‘PAs’) play a distinct role because of the large number of congeners occurring in nature and the pronounced toxicity of some congeners. Several PAs are hepatotoxic in humans, experimental and farm animals and were shown to be potent hepatocarcinogens in laboratory rodents. Although the general mode of action leading to toxicity has been elucidated, i.e., being mediated by metabolic conversion of the parent molecule into a highly reactive electrophile capable of attacking cellular target molecules, major questions related to the risk assessment of PAs remain unresolved. It was the aim of a workshop held in September 2018 to shed more light on the occurrence, exposure, mode of action, toxicokinetics and –dynamics of PAs to improve the scientific basis for an advanced toxicological risk assessment. The contributions in nine chapters describe the scientific progress using advanced analytical methods, studies in subcellular fractions, cell culture, experimental animals and humans and the use of PBPK modeling and structure-activity relationship considerations aiming at a better understanding of PA toxicity and genotoxicity. Since PAs differ considerably in their toxic potencies and substantial species differences in sensitivity towards PA exposure exist, a special emphasis was placed on these issues.

Original languageEnglish
Article number111107
JournalFood and Chemical Toxicology
Volume136
DOIs
Publication statusPublished - Feb 2020

Fingerprint

Pyrrolizidine Alkaloids
pyrrolizidine alkaloids
Risk assessment
risk assessment
Toxicity
toxicity
Food
Subcellular Fractions
laboratory animals
Poisons
mechanism of action
Domestic Animals
Animals
Structure-Activity Relationship
Toxicology
Rodentia
subcellular fractions
Molecules
Cell Culture Techniques
genotoxicity

Keywords

  • Food safety
  • Hepatocarcinogenicity
  • Liver toxicity
  • Natural toxins
  • Pyrrolizidine alkaloids

Cite this

Schrenk, Dieter ; Gao, Lan ; Lin, Ge ; Mahony, Catherine ; Mulder, Patrick P.J. ; Peijnenburg, Ad ; Pfuhler, Stefan ; Rietjens, Ivonne M.C.M. ; Rutz, Lukas ; Steinhoff, Barbara ; These, Anja. / Pyrrolizidine alkaloids in food and phytomedicine : Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review. In: Food and Chemical Toxicology. 2020 ; Vol. 136.
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Pyrrolizidine alkaloids in food and phytomedicine : Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review. / Schrenk, Dieter; Gao, Lan; Lin, Ge; Mahony, Catherine; Mulder, Patrick P.J.; Peijnenburg, Ad; Pfuhler, Stefan; Rietjens, Ivonne M.C.M.; Rutz, Lukas; Steinhoff, Barbara; These, Anja.

In: Food and Chemical Toxicology, Vol. 136, 111107, 02.2020.

Research output: Contribution to journalArticleAcademicpeer-review

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T2 - Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review

AU - Schrenk, Dieter

AU - Gao, Lan

AU - Lin, Ge

AU - Mahony, Catherine

AU - Mulder, Patrick P.J.

AU - Peijnenburg, Ad

AU - Pfuhler, Stefan

AU - Rietjens, Ivonne M.C.M.

AU - Rutz, Lukas

AU - Steinhoff, Barbara

AU - These, Anja

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