Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups

Judith G.M. Bergboer, Geuranne S. Tjabringa, Marijke Kamsteeg, Ivonne M.J.J. Van Vlijmen-Willems, Diana Rodijk-Olthuis, Patrick A.M. Jansen, Jean Yves Thuret, Masashi Narita, Akemi Ishida-Yamamoto, Patrick L.J.M. Zeeuwen, Joost Schalkwijk*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

68 Citations (Scopus)

Abstract

Deletion of the late cornified envelope (LCE) genes LCE3B and LCE3C has recently been identified as a risk factor for psoriasis. Expression of 16 LCE genes of LCE groups 1, 2, 3, 5, and 6 was examined in vivo and in vitro. Quantitative PCR demonstrated that moderate to high LCE expression was largely confined to skin and a few oropharyngeal tissues. Genes of the LCE3 group demonstrated increased expression in lesional psoriatic epidermis and were induced after superficial injury of normal skin, whereas expression of members of other LCE groups was down-regulated under these conditions. Immunohistochemistry and immunoelectron microscopy demonstrated that LCE2 protein expression was restricted to the uppermost granular layer and the stratum corneum. Stimulation of in vitro reconstructed skin by several psoriasis-associated cytokines resulted in induction of LCE3 members. The data suggest that LCE proteins of groups 1, 2, 5, and 6 are involved in normal skin barrier function, whereas LCE3 genes encode proteins involved in barrier repair after injury or inflammation. These findings may provide clues to the mechanistic role of LCE3B/C deletion in psoriasis.

Original languageEnglish
Pages (from-to)1470-1477
Number of pages8
JournalAmerican Journal of Pathology
Volume178
Issue number4
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

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