TY - JOUR
T1 - Pseudoxylallemycins A-F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802
T2 - A Competitor of Fungus-Growing Termite Cultivars
AU - Guo, Huijuan
AU - Kreuzenbeck, Nina B.
AU - Otani, Saria
AU - Garcia-Altares, Maria
AU - Dahse, Hans Martin
AU - Weigel, Christiane
AU - Aanen, Duur K.
AU - Hertweck, Christian
AU - Poulsen, Michael
AU - Beemelmanns, Christine
PY - 2016
Y1 - 2016
N2 - Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.
AB - Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.
U2 - 10.1021/acs.orglett.6b01437
DO - 10.1021/acs.orglett.6b01437
M3 - Article
AN - SCOPUS:84978628184
VL - 18
SP - 3338
EP - 3341
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 14
ER -