The invention provides antigenic sites of PRRSV isolates. The antigenic sites are neutralizing, conserved, non-conserved and conformational, can elicit antibodies and are found on protein GP4 and N encoded by ORF4 and ORF7 of PRRSV. The peptide sequences identified by the sites can be incorporated in vaccines directed against PRRS and in diagnostic tests for PRRS. Also, discriminating tests can be developed that can be used next to marker vaccines in programs designed to eradicate PRRS from pig herds.
|Publication status||Published - 1997|
van Nieuwstadt, A. P., Meulenberg, J. J. M., & van Essen-Zandbergen, A. (1997). PRRSV antigenic sites identifying peptide sequences of PRRS virus for use in vaccines or diagnostic assays. (Patent No. WO9850426). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=9850426A1&KC=A1&FT=D&ND=4&date=19981112&DB=EPODOC&locale=en_EP