Proteomic footprints of a member of Glossinavirus (Hytrosaviridae): An expeditious approach to virus control strategies in tsetse factories

H.M. Kariithi, J.W.M. van Lent, M.M. van Oers, A.M.M. Abd-Alla, J.M. Vlak

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


The Glossinavirus (Glossina pallidipes salivary gland hypertrophy virus (GpSGHV)) is a rod-shaped enveloped insect virus containing a 190,032bp-long, circular dsDNA genome. The virus is pathogenic for the tsetse fly Glossina pallidipes and has been associated with the collapse of selected mass-reared colonies. Maintenance of productive fly colonies is critical to tsetse and trypanosomiasis eradication in sub-Saharan Africa using the Sterile Insect Technique. Proteomics, an approach to define the expressed protein complement of a genome, was used to further our understanding of the protein composition, morphology, morphogenesis and pathology of GpSGHV. Additionally, this approach provides potential targets for novel and sustainable molecular-based antiviral strategies to control viral infections in tsetse colonies. To achieve this goal, identification of key protein partners involved in virus transmission is required. In this review, we integrate the available data on GpSGHV proteomics to assess the impact of viral infections on host metabolism and to understand the contributions of such perturbations to viral pathogenesis. The relevance of the proteome findings to tsetse and trypanosomiasis management in sub-Sahara Africa is also considered.
Original languageEnglish
Pages (from-to)S26-S31
JournalJournal of Invertebrate Pathology
Issue numbersuppl. 1
Publication statusPublished - 2013


  • salivary-gland hypertrophy
  • mass-spectrometry
  • dna virus
  • morsitans-centralis
  • pallidipes diptera
  • musca-domestica
  • mature virion
  • female tsetse
  • protein
  • glossinidae


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