Proteome analysis suggests that mitochondrial dysfunction in stressed endothelial cells is reversed by a soy extract and isolated isoflavones

D. Fuchs, B. Dirscherl, J.H. Schroot, H. Daniel, U. Wenzel

    Research output: Contribution to journalArticleAcademicpeer-review

    14 Citations (Scopus)

    Abstract

    Apoptosis is a driving force in atherosclerosis development. A soy extract or a combination of the soy isoflavones genistein and daidzein inhibited apoptosis induced by oxidized LDL in endothelial cells. Proteome analysis revealed that the LDL-induced alterations of numerous proteins were reversed by the extract and the genistein/daidzein mixture but only three protein entities, all functionally linked to mitochondrial dysfunction, were regulated in common by both treatments.
    Original languageEnglish
    Pages (from-to)2132-2142
    JournalJournal of Proteome Research
    Volume6
    Issue number6
    DOIs
    Publication statusPublished - 2007

    Keywords

    • low-density-lipoprotein
    • smooth-muscle cells
    • oxidized-ldl
    • platelet-aggregation
    • hyperglycemic damage
    • phyto-estrogens
    • genistein
    • pathways
    • superoxide
    • expression

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