Protective effects of high-potency FMDV O1 Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination

Jacquelyn Horsington*, Claudia Beascoechea Perez, Eduardo Maradei, Sabrina Galdo Novo, Jose L. Gonzales, Nagendrakumar B. Singanallur, Paula Bonastre, Wilna Vosloo

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Serotype O foot-and-mouth disease (FMD) virus belonging to the SEA topotype continues to be a significant problem in the Eastern Asia region, with outbreaks in Japan and South Korea resulting in the culling of over 3.5 million cattle and pigs in recent years. High-potency O1 Manisa vaccine was previously shown to provide protection in cattle 21. days post vaccination (dpv) following challenge with a representative virus, O/SKR/2010. This study tested the ability of the O1 Manisa vaccine to protect cattle from infection and disease with the O/SKR/2010 virus within just 4 or 7. days post vaccination. The vaccine protected 50% of cattle from clinical disease when administered 7. days prior to challenge, but was not protective with just 4. days between vaccination and challenge. Viraemia was significantly reduced in animals challenged 7 dpv but not 4 dpv, compared to unvaccinated controls, however, there were no effects on the level of virus detected in nasal and oral secretions regardless of vaccination time. The level of neutralising antibodies detected in cattle challenged 7 dpv correlated with protection from clinical disease. All animals seroconverted to FMDV non-structural proteins, suggesting no sterile protection. An equal number of animals became persistently infected in both vaccine groups. The results indicated that high-potency O1 Manisa vaccine administered just 7. days prior to challenge should provide partial protection of cattle if an outbreak of O/SKR/2010, or related viruses, occurs, and would be useful to limit spread of FMDV when used in conjunction with other control measures.
Original languageEnglish
Pages (from-to)5179-5185
JournalVaccine
Volume35
Issue number38
DOIs
Publication statusPublished - 2017

Fingerprint

Foot-and-mouth disease virus
protective effect
Vaccination
Vaccines
vaccination
vaccines
cattle
Cattle Diseases
Viruses
viruses
Disease Outbreaks
Foot-and-Mouth Disease Virus
animals
culling (animals)
Republic of Korea
Far East
Viremia
viremia
South Korea
Neutralizing Antibodies

Keywords

  • Cattle
  • Foot-and-mouth disease virus
  • Heterologous challenge
  • Vaccine efficacy

Cite this

Horsington, J., Perez, C. B., Maradei, E., Novo, S. G., Gonzales, J. L., Singanallur, N. B., ... Vosloo, W. (2017). Protective effects of high-potency FMDV O1 Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination. Vaccine, 35(38), 5179-5185. https://doi.org/10.1016/j.vaccine.2017.07.102
Horsington, Jacquelyn ; Perez, Claudia Beascoechea ; Maradei, Eduardo ; Novo, Sabrina Galdo ; Gonzales, Jose L. ; Singanallur, Nagendrakumar B. ; Bonastre, Paula ; Vosloo, Wilna. / Protective effects of high-potency FMDV O1 Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination. In: Vaccine. 2017 ; Vol. 35, No. 38. pp. 5179-5185.
@article{32678f13b75348648fcf10c41eef9a01,
title = "Protective effects of high-potency FMDV O1 Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination",
abstract = "Serotype O foot-and-mouth disease (FMD) virus belonging to the SEA topotype continues to be a significant problem in the Eastern Asia region, with outbreaks in Japan and South Korea resulting in the culling of over 3.5 million cattle and pigs in recent years. High-potency O1 Manisa vaccine was previously shown to provide protection in cattle 21. days post vaccination (dpv) following challenge with a representative virus, O/SKR/2010. This study tested the ability of the O1 Manisa vaccine to protect cattle from infection and disease with the O/SKR/2010 virus within just 4 or 7. days post vaccination. The vaccine protected 50{\%} of cattle from clinical disease when administered 7. days prior to challenge, but was not protective with just 4. days between vaccination and challenge. Viraemia was significantly reduced in animals challenged 7 dpv but not 4 dpv, compared to unvaccinated controls, however, there were no effects on the level of virus detected in nasal and oral secretions regardless of vaccination time. The level of neutralising antibodies detected in cattle challenged 7 dpv correlated with protection from clinical disease. All animals seroconverted to FMDV non-structural proteins, suggesting no sterile protection. An equal number of animals became persistently infected in both vaccine groups. The results indicated that high-potency O1 Manisa vaccine administered just 7. days prior to challenge should provide partial protection of cattle if an outbreak of O/SKR/2010, or related viruses, occurs, and would be useful to limit spread of FMDV when used in conjunction with other control measures.",
keywords = "Cattle, Foot-and-mouth disease virus, Heterologous challenge, Vaccine efficacy",
author = "Jacquelyn Horsington and Perez, {Claudia Beascoechea} and Eduardo Maradei and Novo, {Sabrina Galdo} and Gonzales, {Jose L.} and Singanallur, {Nagendrakumar B.} and Paula Bonastre and Wilna Vosloo",
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Horsington, J, Perez, CB, Maradei, E, Novo, SG, Gonzales, JL, Singanallur, NB, Bonastre, P & Vosloo, W 2017, 'Protective effects of high-potency FMDV O1 Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination', Vaccine, vol. 35, no. 38, pp. 5179-5185. https://doi.org/10.1016/j.vaccine.2017.07.102

Protective effects of high-potency FMDV O1 Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination. / Horsington, Jacquelyn; Perez, Claudia Beascoechea; Maradei, Eduardo; Novo, Sabrina Galdo; Gonzales, Jose L.; Singanallur, Nagendrakumar B.; Bonastre, Paula; Vosloo, Wilna.

In: Vaccine, Vol. 35, No. 38, 2017, p. 5179-5185.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Protective effects of high-potency FMDV O1 Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination

AU - Horsington, Jacquelyn

AU - Perez, Claudia Beascoechea

AU - Maradei, Eduardo

AU - Novo, Sabrina Galdo

AU - Gonzales, Jose L.

AU - Singanallur, Nagendrakumar B.

AU - Bonastre, Paula

AU - Vosloo, Wilna

PY - 2017

Y1 - 2017

N2 - Serotype O foot-and-mouth disease (FMD) virus belonging to the SEA topotype continues to be a significant problem in the Eastern Asia region, with outbreaks in Japan and South Korea resulting in the culling of over 3.5 million cattle and pigs in recent years. High-potency O1 Manisa vaccine was previously shown to provide protection in cattle 21. days post vaccination (dpv) following challenge with a representative virus, O/SKR/2010. This study tested the ability of the O1 Manisa vaccine to protect cattle from infection and disease with the O/SKR/2010 virus within just 4 or 7. days post vaccination. The vaccine protected 50% of cattle from clinical disease when administered 7. days prior to challenge, but was not protective with just 4. days between vaccination and challenge. Viraemia was significantly reduced in animals challenged 7 dpv but not 4 dpv, compared to unvaccinated controls, however, there were no effects on the level of virus detected in nasal and oral secretions regardless of vaccination time. The level of neutralising antibodies detected in cattle challenged 7 dpv correlated with protection from clinical disease. All animals seroconverted to FMDV non-structural proteins, suggesting no sterile protection. An equal number of animals became persistently infected in both vaccine groups. The results indicated that high-potency O1 Manisa vaccine administered just 7. days prior to challenge should provide partial protection of cattle if an outbreak of O/SKR/2010, or related viruses, occurs, and would be useful to limit spread of FMDV when used in conjunction with other control measures.

AB - Serotype O foot-and-mouth disease (FMD) virus belonging to the SEA topotype continues to be a significant problem in the Eastern Asia region, with outbreaks in Japan and South Korea resulting in the culling of over 3.5 million cattle and pigs in recent years. High-potency O1 Manisa vaccine was previously shown to provide protection in cattle 21. days post vaccination (dpv) following challenge with a representative virus, O/SKR/2010. This study tested the ability of the O1 Manisa vaccine to protect cattle from infection and disease with the O/SKR/2010 virus within just 4 or 7. days post vaccination. The vaccine protected 50% of cattle from clinical disease when administered 7. days prior to challenge, but was not protective with just 4. days between vaccination and challenge. Viraemia was significantly reduced in animals challenged 7 dpv but not 4 dpv, compared to unvaccinated controls, however, there were no effects on the level of virus detected in nasal and oral secretions regardless of vaccination time. The level of neutralising antibodies detected in cattle challenged 7 dpv correlated with protection from clinical disease. All animals seroconverted to FMDV non-structural proteins, suggesting no sterile protection. An equal number of animals became persistently infected in both vaccine groups. The results indicated that high-potency O1 Manisa vaccine administered just 7. days prior to challenge should provide partial protection of cattle if an outbreak of O/SKR/2010, or related viruses, occurs, and would be useful to limit spread of FMDV when used in conjunction with other control measures.

KW - Cattle

KW - Foot-and-mouth disease virus

KW - Heterologous challenge

KW - Vaccine efficacy

U2 - 10.1016/j.vaccine.2017.07.102

DO - 10.1016/j.vaccine.2017.07.102

M3 - Article

VL - 35

SP - 5179

EP - 5185

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 38

ER -