Protection against diarrhea associated with Giardia intestinalis is lost with Multi-Nutrient Supplementation: A Study in Tanzanian Children

J. Veenemans, T. Mank, M. Ottenhof, A.Y. Baidjoe, E.V. Mbugi, A.Y. Demir, J.P.M. Wielders, H.F.J. Savelkoul, J.C.M. Verhoef

Research output: Contribution to journalArticleAcademicpeer-review

55 Citations (Scopus)

Abstract

Background - Asymptomatic carriage of Giardia intestinalis is highly prevalent among children in developing countries, and evidence regarding its role as a diarrhea-causing agent in these settings is controversial. Impaired linear growth and cognition have been associated with giardiasis, presumably mediated by malabsorption of nutrients. In a prospective cohort study, we aim to compare diarrhea rates in pre-school children with and without Giardia infection. Because the study was conducted in the context of an intervention trial assessing the effects of multi-nutrients on morbidity, we also assessed how supplementation influenced the relationship between Giardia and diarrhoea rates, and to what extent Giardia modifies the intervention effect on nutritional status. Methods and Findings - Data were collected in the context of a randomized placebo-controlled efficacy trial with 2×2 factorial design assessing the effects of zinc and/or multi-micronutrients on morbidity (n = 612; height-for-age z-score
Original languageEnglish
Article numbere1158
Number of pages10
JournalPLoS Neglected Tropical Diseases
Volume5
Issue number6
DOIs
Publication statusPublished - 2011

Keywords

  • israeli bedouin infants
  • lamblia infection
  • protozoal parasites
  • helicobacter-pylori
  • natural-history
  • young-children
  • bangladesh
  • childhood
  • disease
  • consequences

Fingerprint Dive into the research topics of 'Protection against diarrhea associated with Giardia intestinalis is lost with Multi-Nutrient Supplementation: A Study in Tanzanian Children'. Together they form a unique fingerprint.

  • Cite this