Prokaryotic Argonautes Function beyond Immunity by Unlinking Replicating Chromosomes

Daan C. Swarts*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Eukaryotic Argonaute proteins strictly mediate RNA-guided RNA interference. In contrast, prokaryotic Argonautes can utilize DNA guides to target complementary DNA sequences to protect their hosts against invading DNA. In this issue of Cell, Jolly and colleagues demonstrate that Thermus thermophilus Argonaute additionally participates in DNA replication by unlinking catenated chromosomes.

Original languageEnglish
Pages (from-to)1381-1383
JournalCell
Volume182
Issue number6
DOIs
Publication statusPublished - 17 Sep 2020

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