Abstract
Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.
| Original language | English |
|---|---|
| Pages (from-to) | 5-11 |
| Journal | Nature Reviews Microbiology |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
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Prokaryotic Argonaute proteins : novel genome-editing tools? / Hegge, Jorrit W.; Swarts, Daan C.; van der Oost, John.
In: Nature Reviews Microbiology, Vol. 16, No. 1, 01.01.2018, p. 5-11.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Prokaryotic Argonaute proteins
T2 - novel genome-editing tools?
AU - Hegge, Jorrit W.
AU - Swarts, Daan C.
AU - van der Oost, John
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.
AB - Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.
U2 - 10.1038/nrmicro.2017.73
DO - 10.1038/nrmicro.2017.73
M3 - Article
VL - 16
SP - 5
EP - 11
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
SN - 1740-1526
IS - 1
ER -