Prokaryotic Argonaute proteins

novel genome-editing tools?

Jorrit W. Hegge, Daan C. Swarts, John van der Oost

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.

Original languageEnglish
Pages (from-to)5-11
JournalNature Reviews Microbiology
Volume16
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Argonaute Proteins
Nucleic Acids
Archaea
RNA Interference
Eukaryota
Proteins
Bacteria
Gene Editing

Cite this

Hegge, Jorrit W. ; Swarts, Daan C. ; van der Oost, John. / Prokaryotic Argonaute proteins : novel genome-editing tools?. In: Nature Reviews Microbiology. 2018 ; Vol. 16, No. 1. pp. 5-11.
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Prokaryotic Argonaute proteins : novel genome-editing tools? / Hegge, Jorrit W.; Swarts, Daan C.; van der Oost, John.

In: Nature Reviews Microbiology, Vol. 16, No. 1, 01.01.2018, p. 5-11.

Research output: Contribution to journalArticleAcademicpeer-review

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