Prokaryotic Argonaute proteins: novel genome-editing tools?

Jorrit W. Hegge, Daan C. Swarts, John van der Oost*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

73 Citations (Scopus)


Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.

Original languageEnglish
Pages (from-to)5-11
JournalNature Reviews Microbiology
Issue number1
Publication statusPublished - 1 Jan 2018


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