Prokaryotic Argonaute proteins: novel genome-editing tools?

Jorrit W. Hegge; Daan C. Swarts; John van der Oost

doi:10.1038/nrmicro.2017.73

Prokaryotic Argonaute proteins: novel genome-editing tools?

Jorrit W. Hegge, Daan C. Swarts, John van der Oost^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

73 Citations (Scopus)

Abstract

Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.

Original language	English
Pages (from-to)	5-11
Journal	Nature Reviews Microbiology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1038/nrmicro.2017.73
Publication status	Published - 1 Jan 2018

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title = "Prokaryotic Argonaute proteins: novel genome-editing tools?",

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Prokaryotic Argonaute proteins: novel genome-editing tools?

Abstract

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