Progress in the development of Lactococcus lactis as a recombinant mucosal vaccine delivery system

P.M. Norton*, R.W.F. Le Page, J.M. Wells

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

The non-pathogenic, non-colonising Gram-positive organism Lactobacillus lactis is beeing developed as an antigen delivery system for mucosal vaccination. A high level expression system has been developed which allows loading of the bacterium with high levels of a heterologous antigen (TTFC) prior to inoculaton. Mucosal inoculaton of one such recombinant strain results in a protective serum antibody response and production of TTFC-specific IgA at mucosal sites.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalFolia Microbiologica
Volume40
Issue number3
DOIs
Publication statusPublished - May 1995
Externally publishedYes

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