Abstract
The non-pathogenic, non-colonising Gram-positive organism Lactobacillus lactis is beeing developed as an antigen delivery system for mucosal vaccination. A high level expression system has been developed which allows loading of the bacterium with high levels of a heterologous antigen (TTFC) prior to inoculaton. Mucosal inoculaton of one such recombinant strain results in a protective serum antibody response and production of TTFC-specific IgA at mucosal sites.
Original language | English |
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Pages (from-to) | 225-230 |
Number of pages | 6 |
Journal | Folia Microbiologica |
Volume | 40 |
Issue number | 3 |
DOIs | |
Publication status | Published - May 1995 |
Externally published | Yes |