Production of resveratrol in recombinant microorganisms

M.J. Beekwilder; R. Wolswinkel; H.H. Jonker; R.D. Hall; C.H. de Vos; A.G. Bovy

doi:10.1128/AEM.00609-06

Production of resveratrol in recombinant microorganisms

M.J. Beekwilder, R. Wolswinkel, H.H. Jonker, R.D. Hall, C.H. de Vos, A.G. Bovy

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185 Citations (Scopus)

Abstract

Resveratrol production in Saccharomyces cerevisiae was compared to that in Escherichia coli. In both systems, 4-coumarate:coenzyme A ligase from tobacco and stilbene synthase from grapes were expressed. When p-coumaric acid was used as the precursor, resveratrol accumulations in the culture medium were observed to be comparable in E. coli (16 mg/liter) and yeast (6 mg/liter)

Original language	English
Pages (from-to)	5670-5672
Journal	Applied and Environmental Microbiology
Volume	72
Issue number	8
DOIs	https://doi.org/10.1128/AEM.00609-06
Publication status	Published - 2006

Keywords

engineered escherichia-coli
saccharomyces-cerevisiae
biosynthesis
pathway

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10.1128/AEM.00609-06

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abstract = "Resveratrol production in Saccharomyces cerevisiae was compared to that in Escherichia coli. In both systems, 4-coumarate:coenzyme A ligase from tobacco and stilbene synthase from grapes were expressed. When p-coumaric acid was used as the precursor, resveratrol accumulations in the culture medium were observed to be comparable in E. coli (16 mg/liter) and yeast (6 mg/liter)",

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AU - Wolswinkel, R.

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AU - de Vos, C.H.

AU - Bovy, A.G.

PY - 2006

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AB - Resveratrol production in Saccharomyces cerevisiae was compared to that in Escherichia coli. In both systems, 4-coumarate:coenzyme A ligase from tobacco and stilbene synthase from grapes were expressed. When p-coumaric acid was used as the precursor, resveratrol accumulations in the culture medium were observed to be comparable in E. coli (16 mg/liter) and yeast (6 mg/liter)

KW - engineered escherichia-coli

KW - saccharomyces-cerevisiae

KW - biosynthesis

KW - pathway

U2 - 10.1128/AEM.00609-06

DO - 10.1128/AEM.00609-06

M3 - Article

SN - 0099-2240

VL - 72

SP - 5670

EP - 5672

JO - Applied and Environmental Microbiology

JF - Applied and Environmental Microbiology

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ER -

Production of resveratrol in recombinant microorganisms

Abstract

Keywords

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