Production of resveratrol in recombinant microorganisms

M.J. Beekwilder, R. Wolswinkel, H.H. Jonker, R.D. Hall, C.H. de Vos, A.G. Bovy

    Research output: Contribution to journalArticleAcademicpeer-review

    149 Citations (Scopus)

    Abstract

    Resveratrol production in Saccharomyces cerevisiae was compared to that in Escherichia coli. In both systems, 4-coumarate:coenzyme A ligase from tobacco and stilbene synthase from grapes were expressed. When p-coumaric acid was used as the precursor, resveratrol accumulations in the culture medium were observed to be comparable in E. coli (16 mg/liter) and yeast (6 mg/liter)
    Original languageEnglish
    Pages (from-to)5670-5672
    JournalApplied and Environmental Microbiology
    Volume72
    Issue number8
    DOIs
    Publication statusPublished - 2006

    Keywords

    • engineered escherichia-coli
    • saccharomyces-cerevisiae
    • biosynthesis
    • pathway

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