Production of neosolaniol by Fusarium tumidum

Claudio Altomare*, Alberto Ritieni, Giancarlo Perrone, Vincenzo Fogliano, Luisa Mannina, Antonio Logrieco

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)


Extracts from autoclaved maize culture of Fusarium tumidum strain R-5823 were toxic towards Artemia salina. Bioassay-guided fractionation of the organic extract led to the isolation of the toxic compound that was identified as the trichothecene toxin neosolaniol (NEOS) by1H,13C nuclear magnetic resonance spectroscopy and low-resolution electronic impact mass spectrometry. The amount of NEOS produced by the strain R-5823 was 300 mg/kg maize culture. NEOS was also detected by HPLC in cultures of four out of seven additional strains of F. tumidum and Gibberella tumida with different origin, in amounts ranging from 1 to 311 mg/kg. This is the first report on the production of a trichothecene toxin by F. tumidum.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
Issue number3
Publication statusPublished - Jun 1995
Externally publishedYes


  • Fusarium tumidum
  • Mycotoxins
  • Neosolaniol
  • Trichothecenes


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