Process for the manufacture of a fermented health-promoting product

J.L. Kiers (Inventor), M.J.R. Nout (Inventor), F.M. Rombouts (Inventor), B.C. Koops (Inventor), K.M.J. van Laere (Inventor), E. Wissing (Inventor), R.J.J. Hagemann (Inventor), J. van der Meulen (Inventor)

Research output: PatentOther research output


The present invention relates to a process that yields a product that can suitably be used in the treatment and prevention of diarrhea without giving rise to any undesirable side-effects. The invention is based on the discovery that aqueous fractions obtained from the fermentation of certain plant materials with fungi, may effectively be used to prevent, manage and/or treat diarrhea. Thus, in one aspect, the invention relates to a process for the manufacture of a health promoting product, said process comprising the subsequent steps of: a) preparing a substrate containing dry matter of which at least 50 wt.s derived from a plant material selected from legume, pulses, fruit, nuts, beans, seeds, grain, tubers and mixtures thereof, said substrate containing between 7.5 and 70 rotein, between 20 and 67 arbohydrates and less than 40 ipids by weight of dry matter, b) inoculating said substrate with a specified fungus, c) allowing the fungus to ferment the substrate for at least 6 hours at a temperature in excess of 25 DEG C, d) isolating an aqueous fraction from the fermentate so obtained, e) drying said aqueous fraction so as to obtain a powder which expresses at least 10 U/g of protease activity. Another aspect of the present invention relates to a composition for use in a method of treating diarrhea, wherein said method comprises administering an effective amount of a powder obtained by the process as described above
Original languageEnglish
Patent numberWO02086136
Priority date25/04/01
Publication statusPublished - 25 Apr 2001

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