Process for the conversion of C-terminal peptide esters or acids to amides employing subtilisin in the presence of ammonium salts

I.F. Eggen; C.G. Boeriu

Process for the conversion of C-terminal peptide esters or acids to amides employing subtilisin in the presence of ammonium salts

I.F. Eggen (Inventor)
, C.G. Boeriu (Inventor)

Research output: Patent

Abstract

The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0. This process is useful in the production of protected or unprotected peptides.

Original language	English
Patent number	WO2009000814
Priority date	25/06/07
Publication status	Published - 31 Dec 2008

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title = "Process for the conversion of C-terminal peptide esters or acids to amides employing subtilisin in the presence of ammonium salts",

abstract = "The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0. This process is useful in the production of protected or unprotected peptides.",

author = "I.F. Eggen and C.G. Boeriu",

year = "2008",

month = dec,

day = "31",

language = "English",

type = "Patent",

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TY - PAT

T1 - Process for the conversion of C-terminal peptide esters or acids to amides employing subtilisin in the presence of ammonium salts

AU - Eggen, I.F.

AU - Boeriu, C.G.

PY - 2008/12/31

Y1 - 2008/12/31

N2 - The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0. This process is useful in the production of protected or unprotected peptides.

AB - The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0. This process is useful in the production of protected or unprotected peptides.

M3 - Patent

M1 - WO2009000814

ER -

Process for the conversion of C-terminal peptide esters or acids to amides employing subtilisin in the presence of ammonium salts

Abstract

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