Process for the conversion of C-terminal peptide esters or acids to amides employing subtilisin in the presence of ammonium salts

I.F. Eggen (Inventor), C.G. Boeriu (Inventor)

    Research output: PatentOther research output

    Abstract

    The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0. This process is useful in the production of protected or unprotected peptides.
    Original languageEnglish
    Patent numberWO2009000814
    Priority date25/06/07
    Publication statusPublished - 31 Dec 2008

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