Process for producing itaconic acid under anaerobic conditions

R.A. Weusthuis (Inventor), K.S. Vuoristo (Inventor), G. Eggink (Inventor), J.P.M. Sanders (Inventor)

Research output: PatentOther research output

Abstract

The present invention relates to a method for the production of itaconic acid, which method comprises fermenting a recombinant cell capable of producing itaconic acid in a suitable fermentation medium, thereby to produce itaconic acid, wherein: (a) the recombinant cell: (i) overexpresses cis-aconitate decarboxylase; and (ii) overexpresses a part of the citric acid cycle and/or has reduced activity of a native metabolic route to acetate and/or lactate; and, optionally, (b) the fermentation is carried out under anaerobic conditions.
Original languageEnglish
Patent numberWO2016131818
Priority date16/02/15
Publication statusPublished - 25 Aug 2016

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aconitate decarboxylase
Fermentation
Citric Acid Cycle
Lactic Acid
Acetates
itaconic acid

Cite this

Weusthuis, R. A., Vuoristo, K. S., Eggink, G., & Sanders, J. P. M. (2016). Process for producing itaconic acid under anaerobic conditions. (Patent No. WO2016131818).
Weusthuis, R.A. (Inventor) ; Vuoristo, K.S. (Inventor) ; Eggink, G. (Inventor) ; Sanders, J.P.M. (Inventor). / Process for producing itaconic acid under anaerobic conditions. Patent No.: WO2016131818.
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Weusthuis, RA, Vuoristo, KS, Eggink, G & Sanders, JPM 2016, Process for producing itaconic acid under anaerobic conditions, Patent No. WO2016131818.

Process for producing itaconic acid under anaerobic conditions. / Weusthuis, R.A. (Inventor); Vuoristo, K.S. (Inventor); Eggink, G. (Inventor); Sanders, J.P.M. (Inventor).

Patent No.: WO2016131818.

Research output: PatentOther research output

TY - PAT

T1 - Process for producing itaconic acid under anaerobic conditions

AU - Weusthuis, R.A.

AU - Vuoristo, K.S.

AU - Eggink, G.

AU - Sanders, J.P.M.

PY - 2016/8/25

Y1 - 2016/8/25

N2 - The present invention relates to a method for the production of itaconic acid, which method comprises fermenting a recombinant cell capable of producing itaconic acid in a suitable fermentation medium, thereby to produce itaconic acid, wherein: (a) the recombinant cell: (i) overexpresses cis-aconitate decarboxylase; and (ii) overexpresses a part of the citric acid cycle and/or has reduced activity of a native metabolic route to acetate and/or lactate; and, optionally, (b) the fermentation is carried out under anaerobic conditions.

AB - The present invention relates to a method for the production of itaconic acid, which method comprises fermenting a recombinant cell capable of producing itaconic acid in a suitable fermentation medium, thereby to produce itaconic acid, wherein: (a) the recombinant cell: (i) overexpresses cis-aconitate decarboxylase; and (ii) overexpresses a part of the citric acid cycle and/or has reduced activity of a native metabolic route to acetate and/or lactate; and, optionally, (b) the fermentation is carried out under anaerobic conditions.

M3 - Patent

M1 - WO2016131818

ER -

Weusthuis RA, Vuoristo KS, Eggink G, Sanders JPM, inventors. Process for producing itaconic acid under anaerobic conditions. WO2016131818. 2016 Aug 25.