Process for producing itaconic acid under anaerobic conditions

R.A. Weusthuis (Inventor), K.S. Vuoristo (Inventor), G. Eggink (Inventor), J.P.M. Sanders (Inventor)

Research output: Patent


The present invention relates to a method for the production of itaconic acid, which method comprises fermenting a recombinant cell capable of producing itaconic acid in a suitable fermentation medium, thereby to produce itaconic acid, wherein: (a) the recombinant cell: (i) overexpresses cis-aconitate decarboxylase; and (ii) overexpresses a part of the citric acid cycle and/or has reduced activity of a native metabolic route to acetate and/or lactate; and, optionally, (b) the fermentation is carried out under anaerobic conditions.
Original languageEnglish
Patent numberWO2016131818
Priority date16/02/15
Publication statusPublished - 25 Aug 2016


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