Probabilistic assessment of the cumulative acute exposure to organophosphorus and carbamate insecticides in the Brazilian diet

E.D. Caldas, P.E. Boon, J. Tressou

    Research output: Contribution to journalArticleAcademicpeer-review

    47 Citations (Scopus)

    Abstract

    In the present study, the cumulative exposure of 25 acetylcholinesterase (AChE) inhibiting pesticides through the consumption of nine fruits and vegetables by the Brazilian population was assessed. Food consumption data were obtained from a household budget survey conducted in all Brazilian states from July 2002 to June 2003. Residue data from 4001 samples were obtained from the Brazilian national monitoring program on pesticide residues. Relative potency factors (RPF) were calculated with methamidophos or acephate as index compounds (IC), using BMD10 or NOAEL for AChE inhibition, mostly in rat brain, obtained from national and international pesticide evaluations. Monocrotophos and triazophos, in addition to aldicarb, had the highest calculated RPF in any scenario. The exposure to AChE inhibiting pesticides for the general population at P99.9, represented 33.6% of the ARfD as methamidophos and 70.2% ARfD as acephate. The exposure calculated as acephate could exceed the ARfD at the upper bound of the 95% confidence interval for this percentile. Exposure for children aged up to 6 years were, on average, 2.4 times higher than the exposure for the general population. Tomato represented about 67% of the total intake of AChE inhibiting pesticides. The highest calculated equivalent residues in tomato, which drove most of the estimated intakes at the high percentiles, were related to the illegal use of monocrotophos and triazophos in this crop
    Original languageEnglish
    Pages (from-to)132-142
    JournalToxicology
    Volume222
    Issue number1-2
    DOIs
    Publication statusPublished - 2006

    Keywords

    • risk-assessment
    • pesticides
    • food

    Fingerprint Dive into the research topics of 'Probabilistic assessment of the cumulative acute exposure to organophosphorus and carbamate insecticides in the Brazilian diet'. Together they form a unique fingerprint.

    Cite this