Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds

W. Goldmann*, P. Stewart, E. Marier, T. Konold, S. Street, O. Windl, A. Ortiz-Pelaez, J. Langeveld

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Scrapie in goats is a transmissible, fatal prion disease, which is endemic in the British goat population. The recent success in defining caprine PRNP gene variants that provide resistance to experimental and natural classical scrapie has prompted the authors to conduct a survey of PRNP genotypes in 10 goat breeds and 52 herds to find goats with the resistant K222 allele. They report here the frequencies in 1236 tested animals of the resistance-associated K222 and several other alleles by breed and herd. Eight animals were found to be heterozygous QK222 goats (0.64 per cent genotype frequency, 95 per cent CI 0.28 to 1.27 per cent) but no homozygous KK222 goats were detected. The K222 allele was found in Saanen, Toggenburg and Anglo-Nubian goats. The fact that only a few goats with the K222 allele have been identified does not preclude the possibility to design and implement successful breeding programmes at national level.

Original languageEnglish
Pages (from-to)168
JournalVeterinary Record
Volume178
Issue number7
DOIs
Publication statusPublished - 2016

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Scrapie
scrapie
prions
Goats
goats
Alleles
herds
Genotype
alleles
genotype
Toggenburg
Nubian (goat breed)
Saanen
Prion Diseases
goat breeds
prion diseases
Prion Proteins
Surveys and Questionnaires
Breeding
animals

Cite this

Goldmann, W., Stewart, P., Marier, E., Konold, T., Street, S., Windl, O., ... Langeveld, J. (2016). Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds. Veterinary Record, 178(7), 168. https://doi.org/10.1136/vr.103521
Goldmann, W. ; Stewart, P. ; Marier, E. ; Konold, T. ; Street, S. ; Windl, O. ; Ortiz-Pelaez, A. ; Langeveld, J. / Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds. In: Veterinary Record. 2016 ; Vol. 178, No. 7. pp. 168.
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Goldmann, W, Stewart, P, Marier, E, Konold, T, Street, S, Windl, O, Ortiz-Pelaez, A & Langeveld, J 2016, 'Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds', Veterinary Record, vol. 178, no. 7, pp. 168. https://doi.org/10.1136/vr.103521

Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds. / Goldmann, W.; Stewart, P.; Marier, E.; Konold, T.; Street, S.; Windl, O.; Ortiz-Pelaez, A.; Langeveld, J.

In: Veterinary Record, Vol. 178, No. 7, 2016, p. 168.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Goldmann, W.

AU - Stewart, P.

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AU - Windl, O.

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AU - Langeveld, J.

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AB - Scrapie in goats is a transmissible, fatal prion disease, which is endemic in the British goat population. The recent success in defining caprine PRNP gene variants that provide resistance to experimental and natural classical scrapie has prompted the authors to conduct a survey of PRNP genotypes in 10 goat breeds and 52 herds to find goats with the resistant K222 allele. They report here the frequencies in 1236 tested animals of the resistance-associated K222 and several other alleles by breed and herd. Eight animals were found to be heterozygous QK222 goats (0.64 per cent genotype frequency, 95 per cent CI 0.28 to 1.27 per cent) but no homozygous KK222 goats were detected. The K222 allele was found in Saanen, Toggenburg and Anglo-Nubian goats. The fact that only a few goats with the K222 allele have been identified does not preclude the possibility to design and implement successful breeding programmes at national level.

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