Primary and secondary oxidative stress in Bacillus

J.M. Mols, T. Abee

Research output: Contribution to journalArticleAcademicpeer-review

78 Citations (Scopus)

Abstract

Coping with oxidative stress originating from oxidizing compounds or reactive oxygen species (ROS), associated with the exposure to agents that cause environmental stresses, is one of the prerequisites for an aerobic lifestyle of Bacillus spp. such as B. subtilis, B. cereus and B. anthracis. This minireview highlights novel insights in the primary oxidative stress response caused by oxidizing compounds including hydrogen peroxide and the secondary oxidative stress responses apparent upon exposure to a range of agents and conditions leading to environmental stresses such as antibiotics, heat and acid. Insights in the pathways and damaging radicals involved have been compiled based among others on transcriptome studies, network analyses and fluorescence techniques for detection of ROS at single cell level. Exploitation of the current knowledge for the control of spoilage and pathogenic bacteria is discussed.
Original languageEnglish
Pages (from-to)1387-1394
JournalEnvironmental Microbiology
Volume13
Issue number6
DOIs
Publication statusPublished - 2011

Keywords

  • gram-positive bacteria
  • global transcriptional response
  • cereus atcc 14579
  • nitric-oxide
  • hydrogen-peroxide
  • radical formation
  • subtilis
  • thiol
  • superoxide
  • resistance

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