Prevalence of phylogroups and O25/ST131 insusceptible and extended-spectrum β-lactamase-producing Escherichia coli isolates, the Netherlands

I.T.M.A. Overdevest*, A.M.C. Bergmans, J.J. Verweij, J. Vissers, N. Bax, E. Snelders, J.A.J.W. Kluytmans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

To assess the distribution of phylogroups and O25/ST131 in the Netherlands, we performed a real-time polymerase chain reaction (PCR) on a collection of 108 wild-type Escherichia coli (WT-EC) and 134 extended-spectrum β-lactamase-producing E. coli (ESBL-EC). Phylogroup B2 was predominant, but ESBL-EC were less likely to belong to this phylogroup (48.5%) than were WT-EC (66.7%; p=0.005). In WT-EC, phylogroups B2 and D seem to be more virulent, having a higher prevalence among midstream urine isolates and blood culture isolates, than in catheter-related urine isolates (83.3% and 87.9% vs. 61.9%; p 0.048). O25/ST131 is associated with ESBL production, being almost absent among phylogroup B2 WT-EC (61.5% vs. 5.6%; p<0.001).

Original languageEnglish
Pages (from-to)570.e1-570.e4
JournalClinical Microbiology and Infection
Volume21
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • Blood culture
  • E.coli
  • Phylogroups
  • Rectal colonization
  • ST131
  • Urine

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