Preparation methods of alginate nanoparticles

J.P. Paques, E. van der Linden, C.J.M. van Rijn, L.M.C. Sagis

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176 Citations (Scopus)


This article reviews available methods for the formation of alginate nano-aggregates, nanocapsules and nanospheres. Primarily, alginate nanoparticles are being prepared by two methods. In the “complexation method”, complex formation on the interface of an oil droplet is used to form alginate nanocapsules, and complex formation in an aqueous solution is used to form alginate nano-aggregates. In a second method w/o emulsification coupled with gelation of the alginate emulsion droplet can be used to formalginate nanospheres. We review advantages and disadvantages of these methods, and give an overview of the properties of the alginate particles produced with these methods.
Original languageEnglish
Pages (from-to)163-171
JournalAdvances in Colloid and Interface Science
Publication statusPublished - 2014


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  • oral insulin delivery
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  • drug-delivery
  • chitosan-alginate
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