Preparation methods of alginate nanoparticles

J.P. Paques, E. van der Linden, C.J.M. van Rijn, L.M.C. Sagis

Research output: Contribution to journalArticleAcademicpeer-review

176 Citations (Scopus)

Abstract

This article reviews available methods for the formation of alginate nano-aggregates, nanocapsules and nanospheres. Primarily, alginate nanoparticles are being prepared by two methods. In the “complexation method”, complex formation on the interface of an oil droplet is used to form alginate nanocapsules, and complex formation in an aqueous solution is used to form alginate nano-aggregates. In a second method w/o emulsification coupled with gelation of the alginate emulsion droplet can be used to formalginate nanospheres. We review advantages and disadvantages of these methods, and give an overview of the properties of the alginate particles produced with these methods.
Original languageEnglish
Pages (from-to)163-171
JournalAdvances in Colloid and Interface Science
Volume209
DOIs
Publication statusPublished - 2014

Keywords

  • electrostatic droplet generation
  • emulsification internal gelation
  • in-vitro characterization
  • viscous polymer-solutions
  • ionotropic pre-gelation
  • oral insulin delivery
  • jet cutting method
  • drug-delivery
  • chitosan-alginate
  • turmeric oil

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