TY - JOUR
T1 - Predictors of health-related quality of life of European food-allergic patients
AU - Saleh-Langenberg, Jacquelien
AU - Goossens, N.J.
AU - Flokstra-De Blok, B.M.J.
AU - Kollen, B.J.
AU - van der Meulen, G.N.
AU - Le, T.M.
AU - Knulst, A.C.
AU - Jedrzejczak-Czechowicz, M.
AU - Kowalski, M.L.
AU - Rokicka, E.
AU - Starosta, P.
AU - De La Hoz Caballer, B.
AU - Vazquez-Cortés, S.
AU - Cerecedo, I.
AU - Barreales, L.
AU - Asero, R.
AU - Clausen, M.
AU - DunnGalvin, A.
AU - Hourihane, J.O.B.
AU - Purohit, A.
AU - Papadopoulos, N.G.
AU - Fernandéz-Rivas, M.
AU - Frewer, L.
AU - Burney, P.
AU - Duiverman, E.J.
AU - Dubois, A.E.J.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Abstract Background Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food-allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food-allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. Methods A total of 648 European food-allergic patients (404 adults, 244 children) completed an age-specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. Results For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto-injector (EAI) contributed to impairment of HRQL. Conclusions In this study, food allergy-related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children.
AB - Abstract Background Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food-allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food-allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. Methods A total of 648 European food-allergic patients (404 adults, 244 children) completed an age-specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. Results For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto-injector (EAI) contributed to impairment of HRQL. Conclusions In this study, food allergy-related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children.
KW - epinephrine auto-injector
KW - Europe
KW - food allergy
KW - food allergy quality-of-life questionnaire
KW - health-related quality of life
U2 - 10.1111/all.12582
DO - 10.1111/all.12582
M3 - Article
C2 - 25627424
AN - SCOPUS:84929960550
SN - 0105-4538
VL - 70
SP - 616
EP - 624
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 6
ER -