A substantial part of the plastic produced worldwide ends up in the environment and degrades into nano- and microplastics. The particles are ubiquitously present in the air and enter the food production chain as contaminants. Ingestion of nano- and microplastics present in food and drinking water, or those present in swallowed lung mucus that contain trapped particles, represent the main route of human exposure. Yet much remains to be studied on the intestinal uptake by humans and the potential this exposure has to result in adverse health effects. Here we review the current knowledge and relate this to lessons learned from the field of nanotoxicology. We discuss how in vitro and in silico approaches can be used to support the risk assessment of nano- and microplastics.
|Title of host publication||Present Knowledge in Food Safety|
|Subtitle of host publication||A Risk-Based Approach through the Food Chain|
|Editors||M.E. Knowles, L.E. Anelich, A.R. Boobis, B. Popping|
|Number of pages||16|
|Publication status||Published - 14 Oct 2022|
- in vitro models
- PBK models