Postprandial interleukin-6 release from skeletal muscle in men with impaired glucose tolerance can be reduced by weight loss

E. Corpeleijn, W.H. Saris, E.H. Jansen, P.M. Roekaerts, E.J.M. Feskens, E.E. Blaak

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)


Context: Obesity and type 2 diabetes mellitus are associated with increased levels of IL-6, a marker of inflammation. Objective: This study addressed the question of whether IL-6 was released from skeletal muscle after a high-fat meal in men with impaired glucose tolerance (IGT), a prediabetic state, and whether IL-6 release could be reduced by weight loss. Design: Skeletal muscle metabolism was studied in men with IGT (n = 11) and compared with men with normal glucose tolerance (NGT, n = 9), matched for body mass index and age. IL-6 flux over skeletal muscle was measured with the forearm model. Eight IGT men were willing to participate in a 12-wk weight loss program and were tested again. Results: IL-6, but not C-reactive protein or TNF- receptor 1 and 2, was released by skeletal muscle. Muscle IL-6 release was higher in IGT than in NGT during fasting (IGT = 2.26 ± 1.89 vs. NGT = 0.87 ± 0.48 fmol*100 ml tissue¿1*min¿1, P = 0.04) and after a meal (mean area under the curve per minute: IGT = 3.48 ± 2.63 vs. NGT = 1.37 ± 0.75 fmol*100 ml tissue¿1*min¿1; P = 0.03). In the IGT men, body weight loss resulted in a decrease of postprandial IL-6 release from skeletal muscle (¿52%; P = 0.04), reaching levels of the obese, NGT controls. Conclusion: The present data suggest that a high-fat meal can evoke IL-6 release from muscle and that the IL-6 release is a consequence rather than a cause of the obese, insulin-resistant, and/or IGT state.
Original languageEnglish
Pages (from-to)5819-5824
JournalJournal of Clinical Endocrinology and Metabolism
Issue number10
Publication statusPublished - 2005


  • necrosis-factor-alpha
  • subcutaneous adipose-tissue
  • type-2 diabetic-patients
  • c-reactive protein
  • insulin-resistance
  • oxidative stress
  • healthy-subjects
  • whole-body
  • short-term
  • tnf-alpha

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