Postprandial fatty acid specific changes in circulating oxylipins in lean and obese men after high-fat challenge tests

K. Strassburg, D. Esser, R.J. Vreeken, T. Hankemeier, M.R. Müller, J.P.M. van Duynhoven, J. van Golde, S.J. van Dijk, L.A. Afman, D.M. Jacobs

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Abstract

Scope Circulating oxylipins may affect peripheral tissues and are assumed to play an important role in endothelial function. They are esterified in triglyceride-rich lipoproteins that are increased after a high-fat (HF) meal, depending on BMI and fatty acid (FA) type. Yet, it is unclear which oxylipins appear in circulation after HF meals differing in FA composition. Methods and results In a double-blind randomized crossover challenge study, we characterized the postprandial oxylipin response after different HF challenges in lean and obese men receiving HF milkshakes, either high in saturated FAs (SFA), monounsaturated FAs (MUFA), or omega 3 (n-3) polyunsaturated FAs (PUFA). Plasma oxylipin profiles were significantly altered at 2 and 4 h after shake consumption when compared to baseline. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derived oxylipins increased after n-3 PUFA shake consumption. MUFA shake consumption increased levels of cytochrome P450 mediated oxylipins. SFA shake consumption led to strong increases in linoleic acid (LA) derived HODEs. No differences were observed between lean and obese individuals at baseline and after any shake consumption. Conclusion e are the first demonstrating acute effects on circulating oxylipins after HF meal challenges. These changes were strongly influenced by different dietary FAs and may affect endothelial function.
Original languageEnglish
Pages (from-to)591-600
JournalMolecular Nutrition & Food Research
Volume58
Issue number3
DOIs
Publication statusPublished - 2014

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Oxylipins
oxylipins
Fatty Acids
Fats
fatty acids
lipids
Meals
testing
milkshakes
Eicosapentaenoic Acid
Docosahexaenoic Acids
acute effects
Linoleic Acid
eicosapentaenoic acid
docosahexaenoic acid
cytochrome P-450
lipoproteins
Cross-Over Studies
Cytochrome P-450 Enzyme System
Lipoproteins

Keywords

  • eicosanoid biology
  • markers
  • health

Cite this

Strassburg, K. ; Esser, D. ; Vreeken, R.J. ; Hankemeier, T. ; Müller, M.R. ; van Duynhoven, J.P.M. ; van Golde, J. ; van Dijk, S.J. ; Afman, L.A. ; Jacobs, D.M. / Postprandial fatty acid specific changes in circulating oxylipins in lean and obese men after high-fat challenge tests. In: Molecular Nutrition & Food Research. 2014 ; Vol. 58, No. 3. pp. 591-600.
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abstract = "Scope Circulating oxylipins may affect peripheral tissues and are assumed to play an important role in endothelial function. They are esterified in triglyceride-rich lipoproteins that are increased after a high-fat (HF) meal, depending on BMI and fatty acid (FA) type. Yet, it is unclear which oxylipins appear in circulation after HF meals differing in FA composition. Methods and results In a double-blind randomized crossover challenge study, we characterized the postprandial oxylipin response after different HF challenges in lean and obese men receiving HF milkshakes, either high in saturated FAs (SFA), monounsaturated FAs (MUFA), or omega 3 (n-3) polyunsaturated FAs (PUFA). Plasma oxylipin profiles were significantly altered at 2 and 4 h after shake consumption when compared to baseline. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derived oxylipins increased after n-3 PUFA shake consumption. MUFA shake consumption increased levels of cytochrome P450 mediated oxylipins. SFA shake consumption led to strong increases in linoleic acid (LA) derived HODEs. No differences were observed between lean and obese individuals at baseline and after any shake consumption. Conclusion e are the first demonstrating acute effects on circulating oxylipins after HF meal challenges. These changes were strongly influenced by different dietary FAs and may affect endothelial function.",
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Postprandial fatty acid specific changes in circulating oxylipins in lean and obese men after high-fat challenge tests. / Strassburg, K.; Esser, D.; Vreeken, R.J.; Hankemeier, T.; Müller, M.R.; van Duynhoven, J.P.M.; van Golde, J.; van Dijk, S.J.; Afman, L.A.; Jacobs, D.M.

In: Molecular Nutrition & Food Research, Vol. 58, No. 3, 2014, p. 591-600.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Postprandial fatty acid specific changes in circulating oxylipins in lean and obese men after high-fat challenge tests

AU - Strassburg, K.

AU - Esser, D.

AU - Vreeken, R.J.

AU - Hankemeier, T.

AU - Müller, M.R.

AU - van Duynhoven, J.P.M.

AU - van Golde, J.

AU - van Dijk, S.J.

AU - Afman, L.A.

AU - Jacobs, D.M.

PY - 2014

Y1 - 2014

N2 - Scope Circulating oxylipins may affect peripheral tissues and are assumed to play an important role in endothelial function. They are esterified in triglyceride-rich lipoproteins that are increased after a high-fat (HF) meal, depending on BMI and fatty acid (FA) type. Yet, it is unclear which oxylipins appear in circulation after HF meals differing in FA composition. Methods and results In a double-blind randomized crossover challenge study, we characterized the postprandial oxylipin response after different HF challenges in lean and obese men receiving HF milkshakes, either high in saturated FAs (SFA), monounsaturated FAs (MUFA), or omega 3 (n-3) polyunsaturated FAs (PUFA). Plasma oxylipin profiles were significantly altered at 2 and 4 h after shake consumption when compared to baseline. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derived oxylipins increased after n-3 PUFA shake consumption. MUFA shake consumption increased levels of cytochrome P450 mediated oxylipins. SFA shake consumption led to strong increases in linoleic acid (LA) derived HODEs. No differences were observed between lean and obese individuals at baseline and after any shake consumption. Conclusion e are the first demonstrating acute effects on circulating oxylipins after HF meal challenges. These changes were strongly influenced by different dietary FAs and may affect endothelial function.

AB - Scope Circulating oxylipins may affect peripheral tissues and are assumed to play an important role in endothelial function. They are esterified in triglyceride-rich lipoproteins that are increased after a high-fat (HF) meal, depending on BMI and fatty acid (FA) type. Yet, it is unclear which oxylipins appear in circulation after HF meals differing in FA composition. Methods and results In a double-blind randomized crossover challenge study, we characterized the postprandial oxylipin response after different HF challenges in lean and obese men receiving HF milkshakes, either high in saturated FAs (SFA), monounsaturated FAs (MUFA), or omega 3 (n-3) polyunsaturated FAs (PUFA). Plasma oxylipin profiles were significantly altered at 2 and 4 h after shake consumption when compared to baseline. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derived oxylipins increased after n-3 PUFA shake consumption. MUFA shake consumption increased levels of cytochrome P450 mediated oxylipins. SFA shake consumption led to strong increases in linoleic acid (LA) derived HODEs. No differences were observed between lean and obese individuals at baseline and after any shake consumption. Conclusion e are the first demonstrating acute effects on circulating oxylipins after HF meal challenges. These changes were strongly influenced by different dietary FAs and may affect endothelial function.

KW - eicosanoid biology

KW - markers

KW - health

U2 - 10.1002/mnfr.201300321

DO - 10.1002/mnfr.201300321

M3 - Article

VL - 58

SP - 591

EP - 600

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

SN - 1613-4125

IS - 3

ER -