Post-translational modification of host proteins in pathogen-triggered defence signalling in plants

I.J.E. Stulemeijer, M.H.A.J. Joosten

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Abstract

Microbial plant pathogens impose a continuous threat to global food production. Similar to animals, an innate immune system allows plants to recognize pathogens and swiftly activate defence. To activate a rapid response, receptor-mediated pathogen perception and subsequent downstream signalling depends on post-translational modification (PTM) of components essential for defence signalling. We discuss different types of PTMs that play a role in mounting plant immunity, which include phosphorylation, glycosylation, ubiquitination, sumoylation, nitrosylation, myristoylation, palmitoylation and glycosylphosphatidylinositol (GPI)-anchoring. PTMs are rapid, reversible, controlled and highly specific, and provide a tool to regulate protein stability, activity and localization. Here, we give an overview of PTMs that modify components essential for defence signalling at the site of signal perception, during secondary messenger production and during signalling in the cytoplasm. In addition, we discuss effectors from pathogens that suppress plant defence responses by interfering with host PTMs.
Original languageEnglish
Pages (from-to)545-560
JournalMolecular Plant Pathology
Volume9
Issue number4
DOIs
Publication statusPublished - 2008

Keywords

  • receptor-like kinase
  • e3 ubiquitin ligase
  • 1-aminocyclopropane-1-carboxylic acid synthase
  • bacterial elicitor flagellin
  • arabidopsis innate immunity
  • programmed cell-death
  • stem rust resistance
  • membrane h+-atpase
  • disease resistance
  • plasma-membrane

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