Population genetic analysis and genome-wide association study of patellar luxation in a Thai population of Pomeranian dogs

C. Wangdee*, P.A.J. Leegwater, H.C.M. Heuven, F.G. van Steenbeek, M. Techakumphu, H.A.W. Hazewinkel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

The genetics of patellar luxation (PL) were investigated in Pomeranian dogs presented at the Small Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University. A cohort of 339 Pomeranian dogs, part of a four-generation pedigree of 842 Pomeranians, was screened for PL from 2006 to 2013. PL was present in 77% of the screened dogs, with 84% having bilateral and 16% unilateral luxation. Medial PL was more common (95%) than lateral PL (2%) or bidirectional PL (3%). The risk of PL was similar in male and female dogs (female:male relative risk 1.11, 95% CI 0.98–1.25). The heritability of PL in the screened population was 0.44 ± 0.04 using a threshold model. A genome-wide association study of PL (48 cases and 48 controls) using a high-density SNP array indicated the possible involvement of 15 chromosomal regions, of which CFA05 and CFA32 remained associated in a larger study involving an additional 128 cases and 7 controls. Candidate genes in these regions may be involved in the pathogenesis of PL in Pomeranian dogs.

Original languageEnglish
Pages (from-to)9-13
JournalResearch in Veterinary Science
Volume111
DOIs
Publication statusPublished - 2017

Keywords

  • Canis lupus familiaris
  • Genome-wide association study
  • Heritability
  • Patellar luxation
  • Prevalence

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