Poor vitamin d status in active pulmonary tuberculosis patients and its correlation with leptin and tnf-α

Qiuzhen Wang*, Aiguo Ma, Tianlin Gao, Yufeng Liu, Lisheng Ren, Lei Han, Boyang Wei, Qian Liu, Chunjiang Dong, Yuze Mu, Duo Li, Frans J. Kok, Evert G. Schouten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Summary Vitamin D deficiency (VDD) is common in tuberculosis (TB) and may be implicated in the etiology of the disease and in its clinical course. The aim of this study was to investigate the association between leptin, inflammatory markers and VD status in TB patients, stratified for presence or absence of diabetes mellitus (DM). Two hundred ninety-nine TB patients were recruited from October 2015 to August 2016. Also, 91 normal controls were included. The information including socio-demographics, dietary intake and living habits was obtained by face-to-face interview. Serum concentrations of leptin and TNF-α, CRP and IL-6 were compared between TB patients with and without severe VDD (SVDD). Pearson’s correlation was used to analyze the association between TNF-α, leptin and 25-hydroxyvitamin D (25(OH)D). A significantly higher prevalence of VDD and SVDD was observed in TB patients compared with normal controls (93.0% vs 70.3%, 65.9% vs 3.3% respectively). Concentration of leptin was significantly lower, while TNF-α higher in TB patients with SVDD compared to those without (p<0.05). After adjustment for con-founders, leptin was positively associated with 25(OH)D (r=0.210, p=0.002) with similar correlation in TB patients with DM (r=0.240, p=0.020). A negative association between TNF-α and 25(OH)D was observed (r=-0.197, p=0.003), which was significant only in the subgroup without DM (r=-0.304, p=0.001). Our findings indicate that a higher VD status in TB patients may be related to higher immune activity and less serious tissue damage, and that this relation is different according to presence or absence of DM co-morbidity.

Original languageEnglish
Pages (from-to)390-398
Number of pages9
JournalJournal of Nutritional Science and Vitaminology
Volume65
Issue number5
DOIs
Publication statusPublished - 31 Oct 2019

Fingerprint

Leptin
Pulmonary Tuberculosis
Vitamins
Tuberculosis
Vitamin D Deficiency
Diabetes Mellitus
Habits
Interleukin-6
Demography
Interviews
Morbidity
Serum

Keywords

  • Co-morbidity
  • Diabetes
  • Immune activity
  • Inflammatory markers
  • Leptin
  • Serum 25(OH)D
  • TNF-α
  • Tuberculosis

Cite this

Wang, Qiuzhen ; Ma, Aiguo ; Gao, Tianlin ; Liu, Yufeng ; Ren, Lisheng ; Han, Lei ; Wei, Boyang ; Liu, Qian ; Dong, Chunjiang ; Mu, Yuze ; Li, Duo ; Kok, Frans J. ; Schouten, Evert G. / Poor vitamin d status in active pulmonary tuberculosis patients and its correlation with leptin and tnf-α. In: Journal of Nutritional Science and Vitaminology. 2019 ; Vol. 65, No. 5. pp. 390-398.
@article{8b535f084c1849a6822387816f79c668,
title = "Poor vitamin d status in active pulmonary tuberculosis patients and its correlation with leptin and tnf-α",
abstract = "Summary Vitamin D deficiency (VDD) is common in tuberculosis (TB) and may be implicated in the etiology of the disease and in its clinical course. The aim of this study was to investigate the association between leptin, inflammatory markers and VD status in TB patients, stratified for presence or absence of diabetes mellitus (DM). Two hundred ninety-nine TB patients were recruited from October 2015 to August 2016. Also, 91 normal controls were included. The information including socio-demographics, dietary intake and living habits was obtained by face-to-face interview. Serum concentrations of leptin and TNF-α, CRP and IL-6 were compared between TB patients with and without severe VDD (SVDD). Pearson’s correlation was used to analyze the association between TNF-α, leptin and 25-hydroxyvitamin D (25(OH)D). A significantly higher prevalence of VDD and SVDD was observed in TB patients compared with normal controls (93.0{\%} vs 70.3{\%}, 65.9{\%} vs 3.3{\%} respectively). Concentration of leptin was significantly lower, while TNF-α higher in TB patients with SVDD compared to those without (p<0.05). After adjustment for con-founders, leptin was positively associated with 25(OH)D (r=0.210, p=0.002) with similar correlation in TB patients with DM (r=0.240, p=0.020). A negative association between TNF-α and 25(OH)D was observed (r=-0.197, p=0.003), which was significant only in the subgroup without DM (r=-0.304, p=0.001). Our findings indicate that a higher VD status in TB patients may be related to higher immune activity and less serious tissue damage, and that this relation is different according to presence or absence of DM co-morbidity.",
keywords = "Co-morbidity, Diabetes, Immune activity, Inflammatory markers, Leptin, Serum 25(OH)D, TNF-α, Tuberculosis",
author = "Qiuzhen Wang and Aiguo Ma and Tianlin Gao and Yufeng Liu and Lisheng Ren and Lei Han and Boyang Wei and Qian Liu and Chunjiang Dong and Yuze Mu and Duo Li and Kok, {Frans J.} and Schouten, {Evert G.}",
year = "2019",
month = "10",
day = "31",
doi = "10.3177/jnsv.65.390",
language = "English",
volume = "65",
pages = "390--398",
journal = "Journal of Nutritional Science and Vitaminology",
issn = "0301-4800",
number = "5",

}

Wang, Q, Ma, A, Gao, T, Liu, Y, Ren, L, Han, L, Wei, B, Liu, Q, Dong, C, Mu, Y, Li, D, Kok, FJ & Schouten, EG 2019, 'Poor vitamin d status in active pulmonary tuberculosis patients and its correlation with leptin and tnf-α', Journal of Nutritional Science and Vitaminology, vol. 65, no. 5, pp. 390-398. https://doi.org/10.3177/jnsv.65.390

Poor vitamin d status in active pulmonary tuberculosis patients and its correlation with leptin and tnf-α. / Wang, Qiuzhen; Ma, Aiguo; Gao, Tianlin; Liu, Yufeng; Ren, Lisheng; Han, Lei; Wei, Boyang; Liu, Qian; Dong, Chunjiang; Mu, Yuze; Li, Duo; Kok, Frans J.; Schouten, Evert G.

In: Journal of Nutritional Science and Vitaminology, Vol. 65, No. 5, 31.10.2019, p. 390-398.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Poor vitamin d status in active pulmonary tuberculosis patients and its correlation with leptin and tnf-α

AU - Wang, Qiuzhen

AU - Ma, Aiguo

AU - Gao, Tianlin

AU - Liu, Yufeng

AU - Ren, Lisheng

AU - Han, Lei

AU - Wei, Boyang

AU - Liu, Qian

AU - Dong, Chunjiang

AU - Mu, Yuze

AU - Li, Duo

AU - Kok, Frans J.

AU - Schouten, Evert G.

PY - 2019/10/31

Y1 - 2019/10/31

N2 - Summary Vitamin D deficiency (VDD) is common in tuberculosis (TB) and may be implicated in the etiology of the disease and in its clinical course. The aim of this study was to investigate the association between leptin, inflammatory markers and VD status in TB patients, stratified for presence or absence of diabetes mellitus (DM). Two hundred ninety-nine TB patients were recruited from October 2015 to August 2016. Also, 91 normal controls were included. The information including socio-demographics, dietary intake and living habits was obtained by face-to-face interview. Serum concentrations of leptin and TNF-α, CRP and IL-6 were compared between TB patients with and without severe VDD (SVDD). Pearson’s correlation was used to analyze the association between TNF-α, leptin and 25-hydroxyvitamin D (25(OH)D). A significantly higher prevalence of VDD and SVDD was observed in TB patients compared with normal controls (93.0% vs 70.3%, 65.9% vs 3.3% respectively). Concentration of leptin was significantly lower, while TNF-α higher in TB patients with SVDD compared to those without (p<0.05). After adjustment for con-founders, leptin was positively associated with 25(OH)D (r=0.210, p=0.002) with similar correlation in TB patients with DM (r=0.240, p=0.020). A negative association between TNF-α and 25(OH)D was observed (r=-0.197, p=0.003), which was significant only in the subgroup without DM (r=-0.304, p=0.001). Our findings indicate that a higher VD status in TB patients may be related to higher immune activity and less serious tissue damage, and that this relation is different according to presence or absence of DM co-morbidity.

AB - Summary Vitamin D deficiency (VDD) is common in tuberculosis (TB) and may be implicated in the etiology of the disease and in its clinical course. The aim of this study was to investigate the association between leptin, inflammatory markers and VD status in TB patients, stratified for presence or absence of diabetes mellitus (DM). Two hundred ninety-nine TB patients were recruited from October 2015 to August 2016. Also, 91 normal controls were included. The information including socio-demographics, dietary intake and living habits was obtained by face-to-face interview. Serum concentrations of leptin and TNF-α, CRP and IL-6 were compared between TB patients with and without severe VDD (SVDD). Pearson’s correlation was used to analyze the association between TNF-α, leptin and 25-hydroxyvitamin D (25(OH)D). A significantly higher prevalence of VDD and SVDD was observed in TB patients compared with normal controls (93.0% vs 70.3%, 65.9% vs 3.3% respectively). Concentration of leptin was significantly lower, while TNF-α higher in TB patients with SVDD compared to those without (p<0.05). After adjustment for con-founders, leptin was positively associated with 25(OH)D (r=0.210, p=0.002) with similar correlation in TB patients with DM (r=0.240, p=0.020). A negative association between TNF-α and 25(OH)D was observed (r=-0.197, p=0.003), which was significant only in the subgroup without DM (r=-0.304, p=0.001). Our findings indicate that a higher VD status in TB patients may be related to higher immune activity and less serious tissue damage, and that this relation is different according to presence or absence of DM co-morbidity.

KW - Co-morbidity

KW - Diabetes

KW - Immune activity

KW - Inflammatory markers

KW - Leptin

KW - Serum 25(OH)D

KW - TNF-α

KW - Tuberculosis

U2 - 10.3177/jnsv.65.390

DO - 10.3177/jnsv.65.390

M3 - Article

VL - 65

SP - 390

EP - 398

JO - Journal of Nutritional Science and Vitaminology

JF - Journal of Nutritional Science and Vitaminology

SN - 0301-4800

IS - 5

ER -