Polyphenols and human health: A prospectus

Francesco Visioli*, Catalina Alarcón de la Lastra, Cristina Andres-Lacueva, Michael Aviram, Conceição Calhau, Alfredo Cassano, Massimo D'Archivio, Ana Faria, Gaëlle Favé, Vincenzo Fogliano, Rafael Llorach, Paola Vitaglione, Mario Zoratti, Marvin Edeas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

233 Citations (Scopus)


The lay press often heralds polyphenols as panacea for all sorts of diseases. The rationale is that their antioxidant activity would prevent free radical damage to macromolecules. However, basic and clinical science is showing that the reality is much more complex than this and that several issues, notably content in foodstuff, bioavailability, or in vivo antioxidant activity are yet to be resolved. We summarize the recent findings concerning the effects of polyphenols on human health, analyze the current limitations at pitfalls, and propose future directions for research.

Original languageEnglish
Pages (from-to)524-546
Number of pages23
JournalCritical Reviews in Food Science and Nutrition
Issue number6
Publication statusPublished - Jul 2011
Externally publishedYes


  • Antioxidants
  • Bioavailability
  • Cancer
  • Cardiovascular disease
  • Metabolomics
  • Polyphenols

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