Polypeptide nanoribbon hydrogels assembled through multiple supramolecular interactions

Y. Yan; A. de Keizer; A.A. Martens; C.L. Pinto Oliveiro; J. Skov Pedersen; F.A. de Wolf; M. Drechsler; M.A. Cohen Stuart; N.A.M. Besseling

doi:10.1021/la901834v

Polypeptide nanoribbon hydrogels assembled through multiple supramolecular interactions

Y. Yan, A. de Keizer, A.A. Martens, C.L. Pinto Oliveiro, J. Skov Pedersen, F.A. de Wolf, M. Drechsler, M.A. Cohen Stuart, N.A.M. Besseling

VLAG

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

We investigated the formation of nanoribbon hydrogels in a mixed system of zinc ions, bis(ligand)s, and triblock peptide copolymers. Using a combination of experimental techniques: dynamic light scattering, cryo-transmission electron microscopy, small-angle X-ray scattering and circular dichroism, we arrived at a model for the formation of nanoribbon hydrogels in which well-defined nanoribbons are formed out of multiple supramolecular interactions: (1) metal coordination that yields supramolecular polyelectrolytes; (2) electrostatic complexation between the supramolecular polyelectrolytes and the oppositely charged blocks of the peptide copolymers; (3) hydrogen bond and (4) hydrophobic interactions that support the secondary and ternary structure of the ribbons; (5) van der Waals interactions that enable bundling of the ribbons.

Original language	English
Pages (from-to)	12899-12908
Journal	Langmuir
Volume	25
Issue number	22
DOIs	https://doi.org/10.1021/la901834v
Publication status	Published - 2009

Keywords

block-copolymer micelles
coacervate core micelles
small-angle scattering
concentrated colloidal suspensions
coordination polymers
circular-dichroism
diblock copolymer
metal-ions
proteins
transition

Access to Document

10.1021/la901834v

Cite this

@article{d5d5c9b43765491084e4bce284073eb9,

title = "Polypeptide nanoribbon hydrogels assembled through multiple supramolecular interactions",

abstract = "We investigated the formation of nanoribbon hydrogels in a mixed system of zinc ions, bis(ligand)s, and triblock peptide copolymers. Using a combination of experimental techniques: dynamic light scattering, cryo-transmission electron microscopy, small-angle X-ray scattering and circular dichroism, we arrived at a model for the formation of nanoribbon hydrogels in which well-defined nanoribbons are formed out of multiple supramolecular interactions: (1) metal coordination that yields supramolecular polyelectrolytes; (2) electrostatic complexation between the supramolecular polyelectrolytes and the oppositely charged blocks of the peptide copolymers; (3) hydrogen bond and (4) hydrophobic interactions that support the secondary and ternary structure of the ribbons; (5) van der Waals interactions that enable bundling of the ribbons.",

keywords = "block-copolymer micelles, coacervate core micelles, small-angle scattering, concentrated colloidal suspensions, coordination polymers, circular-dichroism, diblock copolymer, metal-ions, proteins, transition",

author = "Y. Yan and {de Keizer}, A. and A.A. Martens and {Pinto Oliveiro}, C.L. and {Skov Pedersen}, J. and {de Wolf}, F.A. and M. Drechsler and {Cohen Stuart}, M.A. and N.A.M. Besseling",

year = "2009",

doi = "10.1021/la901834v",

language = "English",

volume = "25",

pages = "12899--12908",

journal = "Langmuir",

issn = "0743-7463",

publisher = "American Chemical Society",

number = "22",

}

TY - JOUR

T1 - Polypeptide nanoribbon hydrogels assembled through multiple supramolecular interactions

AU - Yan, Y.

AU - de Keizer, A.

AU - Martens, A.A.

AU - Pinto Oliveiro, C.L.

AU - Skov Pedersen, J.

AU - de Wolf, F.A.

AU - Drechsler, M.

AU - Cohen Stuart, M.A.

AU - Besseling, N.A.M.

PY - 2009

Y1 - 2009

N2 - We investigated the formation of nanoribbon hydrogels in a mixed system of zinc ions, bis(ligand)s, and triblock peptide copolymers. Using a combination of experimental techniques: dynamic light scattering, cryo-transmission electron microscopy, small-angle X-ray scattering and circular dichroism, we arrived at a model for the formation of nanoribbon hydrogels in which well-defined nanoribbons are formed out of multiple supramolecular interactions: (1) metal coordination that yields supramolecular polyelectrolytes; (2) electrostatic complexation between the supramolecular polyelectrolytes and the oppositely charged blocks of the peptide copolymers; (3) hydrogen bond and (4) hydrophobic interactions that support the secondary and ternary structure of the ribbons; (5) van der Waals interactions that enable bundling of the ribbons.

AB - We investigated the formation of nanoribbon hydrogels in a mixed system of zinc ions, bis(ligand)s, and triblock peptide copolymers. Using a combination of experimental techniques: dynamic light scattering, cryo-transmission electron microscopy, small-angle X-ray scattering and circular dichroism, we arrived at a model for the formation of nanoribbon hydrogels in which well-defined nanoribbons are formed out of multiple supramolecular interactions: (1) metal coordination that yields supramolecular polyelectrolytes; (2) electrostatic complexation between the supramolecular polyelectrolytes and the oppositely charged blocks of the peptide copolymers; (3) hydrogen bond and (4) hydrophobic interactions that support the secondary and ternary structure of the ribbons; (5) van der Waals interactions that enable bundling of the ribbons.

KW - block-copolymer micelles

KW - coacervate core micelles

KW - small-angle scattering

KW - concentrated colloidal suspensions

KW - coordination polymers

KW - circular-dichroism

KW - diblock copolymer

KW - metal-ions

KW - proteins

KW - transition

U2 - 10.1021/la901834v

DO - 10.1021/la901834v

M3 - Article

SN - 0743-7463

VL - 25

SP - 12899

EP - 12908

JO - Langmuir

JF - Langmuir

IS - 22

ER -

Polypeptide nanoribbon hydrogels assembled through multiple supramolecular interactions

Abstract

Keywords

Access to Document

Fingerprint

Cite this