Plasminogen activator inhibitor-type I: its plasma determinants and relation with cardiovascular risk

T. Hoekstra, J.M. Geleijnse, E.G. Schouten, C. Kluft

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67 Citations (Scopus)


The habitual level of PAI-1 is influenced by many factors, of which obesity and insulin resistance are the most important. It is possible to reduce plasma PAI-1 by changes in life style, e.g. weight reduction and physical activity. Data on potential interactions between environmental and metabolic variables on one hand, and the 4G/5G-polymorphism on the other hand, are still scarce. It becomes more and more clear that PAI-1 may possibly not be a major (causal) factor in cardiovascular disease, but its role in inflammation deserves further attention. In the presence of the 4G-allele not only the PAI-1 response was more pronounced, but also the response of other acute-phase reactants, which implies that the increases of these reactants are secondary to the increase in PAI-1. A myocardial infarction also provokes an acute phase response. It can thus be hypothesized that the 4G-allele might exacerbate tissue injury during the acute phase after a myocardial infarction, and thereby negatively affect the prognosis
Original languageEnglish
Pages (from-to)861-872
JournalThrombosis and Haemostasis
Issue number5
Publication statusPublished - 2004


  • hormone-replacement therapy
  • human-endothelial-cells
  • acute myocardial-infarction
  • coronary-artery-disease
  • human adipose-tissue
  • healthy postmenopausal women
  • 4g/5g promoter polymorphism
  • insulin-resistance syndrome
  • gene-environment interaction
  • depende


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