Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae

M. Rozwandowicz, M.S.M. Brouwer, J. Fischer, J.A. Wagenaar, B. Gonzalez-Zorn, B. Guerra, D.J. Mevius, J. Hordijk*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

133 Citations (Scopus)

Abstract

Bacterial antimicrobial resistance (AMR) is constantly evolving and horizontal gene transfer through plasmids plays a major role. The identification of plasmid characteristics and their association with different bacterial hosts provides crucial knowledge that is essential to understand the contribution of plasmids to the transmission of AMR determinants. Molecular identification of plasmid and strain genotypes elicits a distinction between spread of AMR genes by plasmids and dissemination of these genes by spread of bacterial clones. For this reason several methods are used to type the plasmids, e.g. PCR-based replicon typing (PBRT) or relaxase typing. Currently, there are 28 known plasmid types in Enterobacteriaceae distinguished by PBRT. Frequently reported plasmids [IncF, IncI, IncA/C, IncL (previously designated IncL/M), IncN and IncH] are the ones that bear the greatest variety of resistance genes. The purpose of this review is to provide an overview of all known AMR-related plasmid families in Enterobacteriaceae, the resistance genes they carry and their geographical distribution.
Original languageEnglish
Pages (from-to)1121-1137
JournalJournal of Antimicrobial Chemotherapy
Volume73
Issue number5
Early online date23 Jan 2018
DOIs
Publication statusPublished - 1 May 2018

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