Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae

M. Rozwandowicz, M.S.M. Brouwer, J. Fischer, J.A. Wagenaar, B. Gonzalez-Zorn, B. Guerra, D.J. Mevius, J. Hordijk

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Abstract

Bacterial antimicrobial resistance (AMR) is constantly evolving and horizontal gene transfer through plasmids plays a major role. The identification of plasmid characteristics and their association with different bacterial hosts provides crucial knowledge that is essential to understand the contribution of plasmids to the transmission of AMR determinants. Molecular identification of plasmid and strain genotypes elicits a distinction between spread of AMR genes by plasmids and dissemination of these genes by spread of bacterial clones. For this reason several methods are used to type the plasmids, e.g. PCR-based replicon typing (PBRT) or relaxase typing. Currently, there are 28 known plasmid types in Enterobacteriaceae distinguished by PBRT. Frequently reported plasmids [IncF, IncI, IncA/C, IncL (previously designated IncL/M), IncN and IncH] are the ones that bear the greatest variety of resistance genes. The purpose of this review is to provide an overview of all known AMR-related plasmid families in Enterobacteriaceae, the resistance genes they carry and their geographical distribution.
Original languageEnglish
Pages (from-to)1121-1137
JournalJournal of Antimicrobial Chemotherapy
Volume73
Issue number5
Early online date23 Jan 2018
DOIs
Publication statusPublished - 1 May 2018

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Enterobacteriaceae
Plasmids
Genes
Replicon
Bacterial Genes
Horizontal Gene Transfer
Polymerase Chain Reaction
Clone Cells
Genotype

Cite this

Rozwandowicz, M., Brouwer, M. S. M., Fischer, J., Wagenaar, J. A., Gonzalez-Zorn, B., Guerra, B., ... Hordijk, J. (2018). Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae. Journal of Antimicrobial Chemotherapy, 73(5), 1121-1137. https://doi.org/10.1093/jac/dkx488
Rozwandowicz, M. ; Brouwer, M.S.M. ; Fischer, J. ; Wagenaar, J.A. ; Gonzalez-Zorn, B. ; Guerra, B. ; Mevius, D.J. ; Hordijk, J. / Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae. In: Journal of Antimicrobial Chemotherapy. 2018 ; Vol. 73, No. 5. pp. 1121-1137.
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Rozwandowicz, M, Brouwer, MSM, Fischer, J, Wagenaar, JA, Gonzalez-Zorn, B, Guerra, B, Mevius, DJ & Hordijk, J 2018, 'Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae' Journal of Antimicrobial Chemotherapy, vol. 73, no. 5, pp. 1121-1137. https://doi.org/10.1093/jac/dkx488

Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae. / Rozwandowicz, M.; Brouwer, M.S.M.; Fischer, J.; Wagenaar, J.A.; Gonzalez-Zorn, B.; Guerra, B.; Mevius, D.J.; Hordijk, J.

In: Journal of Antimicrobial Chemotherapy, Vol. 73, No. 5, 01.05.2018, p. 1121-1137.

Research output: Contribution to journalArticleAcademicpeer-review

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AB - Bacterial antimicrobial resistance (AMR) is constantly evolving and horizontal gene transfer through plasmids plays a major role. The identification of plasmid characteristics and their association with different bacterial hosts provides crucial knowledge that is essential to understand the contribution of plasmids to the transmission of AMR determinants. Molecular identification of plasmid and strain genotypes elicits a distinction between spread of AMR genes by plasmids and dissemination of these genes by spread of bacterial clones. For this reason several methods are used to type the plasmids, e.g. PCR-based replicon typing (PBRT) or relaxase typing. Currently, there are 28 known plasmid types in Enterobacteriaceae distinguished by PBRT. Frequently reported plasmids [IncF, IncI, IncA/C, IncL (previously designated IncL/M), IncN and IncH] are the ones that bear the greatest variety of resistance genes. The purpose of this review is to provide an overview of all known AMR-related plasmid families in Enterobacteriaceae, the resistance genes they carry and their geographical distribution.

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Rozwandowicz M, Brouwer MSM, Fischer J, Wagenaar JA, Gonzalez-Zorn B, Guerra B et al. Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae. Journal of Antimicrobial Chemotherapy. 2018 May 1;73(5):1121-1137. https://doi.org/10.1093/jac/dkx488