Plasma intestinal fatty acid binding protein (I-FABP) concentrations increase following intestinal ischemia in pigs

T.A. Niewold, M. Meinen, J. van der Meulen

    Research output: Contribution to journalArticleAcademicpeer-review

    46 Citations (Scopus)

    Abstract

    Intestinal fatty acid binding protein (I-FABP) is an intracellular epithelial protein in the intestinal mucosa of many animals. IFABP appears in the circulation following epithelial damage, and in humans, is proven to be a parameter for damage to the mucosa. In this paper, an ELISA test designed for human I-FABP analysis was used to assay pig blood samples. The test recognized I-FABP cloned from pig small intestine and expressed in Escherichia coli. Furthermore, in our experimental model of (low flow) intestinal ischemia and reperfusion a significant rise in plasma I-FABP concentrations 15-30 min after clamping of the mesenteric artery was demonstrated. This is the first report that in pigs circulating I-FABP is a useful marker for (mild) intestinal injury, and could possibly be used to monitor (intestinal) health in clinical practice. (C) 2004 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)89-91
    JournalResearch in Veterinary Science
    Volume77
    DOIs
    Publication statusPublished - 2004

    Keywords

    • injury
    • infarction
    • disease
    • marker

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