Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women

M.M. Joosten, M.G.J. Balvers, K.C.M. Verhoeckx, H.F.J. Hendriks, R.F. Witkamp

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Abstract

N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake. We hypothesized that i) NAE plasma levels are associated with levels of total free fatty acids (FFAs) and their precursor fatty acid in fasting and non-fasting conditions and ii) moderate alcohol consumption alters non-fasting NAE levels. In a fasting and non-fasting study we sampled blood for measurements of specific NAEs and FFAs. In the fasting study blood was drawn after an overnight fast in 22 postmenopausal women. In the non-fasting study blood was sampled before and frequently after a standardized lunch with beer or alcohol-free beer in 19 premenopausal women. Fasting AEA levels correlated with total FFAs (r = 0.84; p <0.001) and arachidonic acid levels (r = 0.42; p <0.05). Similar results were observed for other NAEs with both total FFAs and their corresponding fatty acid precursors. In addition, AEA (r = 0.66; p <0.01) and OEA levels (r = 0.49; p
Original languageEnglish
Article number49
Number of pages6
JournalNutrition & Metabolism
Volume7
DOIs
Publication statusPublished - 2010

Keywords

  • endocannabinoid system
  • food-intake
  • obesity
  • dysregulation
  • activation
  • appetite
  • adipose
  • insulin
  • brain

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