Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women

M.M. Joosten, M.G.J. Balvers, K.C.M. Verhoeckx, H.F.J. Hendriks, R.F. Witkamp

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)

Abstract

N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake. We hypothesized that i) NAE plasma levels are associated with levels of total free fatty acids (FFAs) and their precursor fatty acid in fasting and non-fasting conditions and ii) moderate alcohol consumption alters non-fasting NAE levels. In a fasting and non-fasting study we sampled blood for measurements of specific NAEs and FFAs. In the fasting study blood was drawn after an overnight fast in 22 postmenopausal women. In the non-fasting study blood was sampled before and frequently after a standardized lunch with beer or alcohol-free beer in 19 premenopausal women. Fasting AEA levels correlated with total FFAs (r = 0.84; p <0.001) and arachidonic acid levels (r = 0.42; p <0.05). Similar results were observed for other NAEs with both total FFAs and their corresponding fatty acid precursors. In addition, AEA (r = 0.66; p <0.01) and OEA levels (r = 0.49; p
Original languageEnglish
Article number49
Number of pages6
JournalNutrition & Metabolism
Volume7
DOIs
Publication statusPublished - 2010

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Nonesterified Fatty Acids
Fasting
Fatty Acids
Appetite Regulation
Lunch
Ethanolamine
Arachidonic Acid
Alcohol Drinking
Alcohols
anandamide
N-acylethanolamines
Lipids

Keywords

  • endocannabinoid system
  • food-intake
  • obesity
  • dysregulation
  • activation
  • appetite
  • adipose
  • insulin
  • brain

Cite this

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title = "Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women",
abstract = "N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake. We hypothesized that i) NAE plasma levels are associated with levels of total free fatty acids (FFAs) and their precursor fatty acid in fasting and non-fasting conditions and ii) moderate alcohol consumption alters non-fasting NAE levels. In a fasting and non-fasting study we sampled blood for measurements of specific NAEs and FFAs. In the fasting study blood was drawn after an overnight fast in 22 postmenopausal women. In the non-fasting study blood was sampled before and frequently after a standardized lunch with beer or alcohol-free beer in 19 premenopausal women. Fasting AEA levels correlated with total FFAs (r = 0.84; p <0.001) and arachidonic acid levels (r = 0.42; p <0.05). Similar results were observed for other NAEs with both total FFAs and their corresponding fatty acid precursors. In addition, AEA (r = 0.66; p <0.01) and OEA levels (r = 0.49; p",
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author = "M.M. Joosten and M.G.J. Balvers and K.C.M. Verhoeckx and H.F.J. Hendriks and R.F. Witkamp",
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Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women. / Joosten, M.M.; Balvers, M.G.J.; Verhoeckx, K.C.M.; Hendriks, H.F.J.; Witkamp, R.F.

In: Nutrition & Metabolism, Vol. 7, 49, 2010.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women

AU - Joosten, M.M.

AU - Balvers, M.G.J.

AU - Verhoeckx, K.C.M.

AU - Hendriks, H.F.J.

AU - Witkamp, R.F.

PY - 2010

Y1 - 2010

N2 - N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake. We hypothesized that i) NAE plasma levels are associated with levels of total free fatty acids (FFAs) and their precursor fatty acid in fasting and non-fasting conditions and ii) moderate alcohol consumption alters non-fasting NAE levels. In a fasting and non-fasting study we sampled blood for measurements of specific NAEs and FFAs. In the fasting study blood was drawn after an overnight fast in 22 postmenopausal women. In the non-fasting study blood was sampled before and frequently after a standardized lunch with beer or alcohol-free beer in 19 premenopausal women. Fasting AEA levels correlated with total FFAs (r = 0.84; p <0.001) and arachidonic acid levels (r = 0.42; p <0.05). Similar results were observed for other NAEs with both total FFAs and their corresponding fatty acid precursors. In addition, AEA (r = 0.66; p <0.01) and OEA levels (r = 0.49; p

AB - N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake. We hypothesized that i) NAE plasma levels are associated with levels of total free fatty acids (FFAs) and their precursor fatty acid in fasting and non-fasting conditions and ii) moderate alcohol consumption alters non-fasting NAE levels. In a fasting and non-fasting study we sampled blood for measurements of specific NAEs and FFAs. In the fasting study blood was drawn after an overnight fast in 22 postmenopausal women. In the non-fasting study blood was sampled before and frequently after a standardized lunch with beer or alcohol-free beer in 19 premenopausal women. Fasting AEA levels correlated with total FFAs (r = 0.84; p <0.001) and arachidonic acid levels (r = 0.42; p <0.05). Similar results were observed for other NAEs with both total FFAs and their corresponding fatty acid precursors. In addition, AEA (r = 0.66; p <0.01) and OEA levels (r = 0.49; p

KW - endocannabinoid system

KW - food-intake

KW - obesity

KW - dysregulation

KW - activation

KW - appetite

KW - adipose

KW - insulin

KW - brain

U2 - 10.1186/1743-7075-7-49

DO - 10.1186/1743-7075-7-49

M3 - Article

VL - 7

JO - Nutrition & Metabolism

JF - Nutrition & Metabolism

SN - 1743-7075

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ER -