Plant phospholipid signaling: "in a nutshell"

Teun Munnik*, Christa Testerink

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

192 Citations (Scopus)

Abstract

Since the discovery of the phosphoinositide/ phospholipase C (PI/PLC) system in animal systems, we know that phospholipids are much more then just structural components of biological membranes. In the beginning, this idea was fairly straightforward. Receptor stimulation activates PLC, which hydrolyses phosphatidylinositol4,5-bisphosphate [PtdIns(4,5)P 2] into two second messengers: inositol 1,4,5- trisphosphate (InsP 3) and diacylglycerol (DG). While InsP 3difuses into the cytosol and triggers the release of calcium from an internal store via ligand-gated calcium channels, DG remains in the membrane where it recruits and activates members of the PKC family. The increase in calcium, together with the change in phosphorylation status, (in)activates a variety of protein targets, leading to a massive reprogramming, allowing the cell to appropriately respond to the extracellular stimulus. Later, it became obvious that not just PLC, but a variety of other phospholipid-metabolizing enzymes were activated, including phospholipase A, phospholipase D, and PI 3-kinase. More recently, it has become apparent that PtdIns4P and PtdIns(4,5)P 2 are not just signal precursors but can also function as signaling molecules themselves. While plants contain most of the components described above, and evidence for their role in cell signaling is progressively increasing, major differences between plants and the mammalian paradigms exist. Below, these are described "in a nutshell."

Original languageEnglish
Pages (from-to)S260-S265
JournalJournal of Lipid Research
Volume50
Issue numberSUPPL.
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

Keywords

  • Phosphatidic acid
  • Phosphoinositide
  • Phospholipase

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