Plant glycans: friend or foe in vaccine development?

Research output: Contribution to journalArticleAcademicpeer-review

54 Citations (Scopus)

Abstract

Plants are an attractive platform for the production of N-glycosylated subunit vaccines. Wild type glycosylation of plants can be exploited to produce vaccines that antigen-presenting cells effectively take up, degrade and present to cells of the adaptive immune system. Alternatively, glycoengineered plants can be used to produce humanized antigens. Glycoengineering also allows the construction of plants that are able to produce vaccines with custom-made N-glycan structures aiding the construction of vaccines that can be delivered to antigen-presenting cells in a target-oriented approach. The knowledge of innate immune receptors and their role in antigen uptake and presentation is rapidly increasing. In this article, aspects of plant glycosylation and immunology are reviewed and we discuss the possibilities to use this knowledge for the rational design of plant-expressed vaccines.
Original languageEnglish
Pages (from-to)835-842
JournalExpert Review Vaccines
Volume9
Issue number8
DOIs
Publication statusPublished - 2010

Keywords

  • reactive carbohydrate determinants
  • human monoclonal-antibody
  • dendritic cells
  • n-glycans
  • transgenic plants
  • linked oligosaccharides
  • glycoprotein allergen
  • antigen presentation
  • secretory pathway
  • in-vitro

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