Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis

B.M. Tyler, S. Tripathy, X. Zhang, P. Dehal, R.H.Y. Jiang, A. Aerts, F.D. Arredondo, L. Baxter, D. Bensasson, J.L. Beynon, J. Chapman, C.M.B. Damasceno, A.E. Dorrance, D. Dou, A.W. Dickerman, I.L. Dubchak, M. Garbelotto, M. Gijzen, S.G. Gordon, F. GoversN.J. Grunwald, W. Huang, K.L. Ivors, R.W. Jones, S. Kamoun, K. Krampis, K.H. Lamour, M.K. Lee, W.H. McDonald, M. Medina, H.J.G. Meijer, E.K. Nordberg, D.J. Maclean, M.D. Ospina-Giraldo, P.F. Morris, V. Phuntumart, N.H. Putnam, S. Rash, J.K.C. Rose, Y. Sakihama, A.A. Salamov, A. Savidor, C.F. Scheuring, B.M. Smith, B.W.S. Sobral, A. Terry, T.A. Torto-Alalibo, J. Win, Z. Xu, H. Zhang, I.V. Grigoriev, D.S. Rokhsar, J.L. Boore

Research output: Contribution to journalArticleAcademicpeer-review

720 Citations (Scopus)

Abstract

Draft genome sequences have been determined for the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum. Oömycetes such as these Phytophthora species share the kingdom Stramenopila with photosynthetic algae such as diatoms, and the presence of many Phytophthora genes of probable phototroph origin supports a photosynthetic ancestry for the stramenopiles. Comparison of the two species' genomes reveals a rapid expansion and diversification of many protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors, and, in particular, a superfamily of 700 proteins with similarity to known oömycete avirulence genes
Original languageEnglish
Pages (from-to)1261-1266
JournalScience
Volume313
Issue number5791
DOIs
Publication statusPublished - 2006

Keywords

  • effector proteins
  • downy mildew
  • resistance
  • arabidopsis
  • avirulence
  • genes
  • locus
  • sojae
  • expression
  • virulence

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