Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis

B.M. Tyler; S. Tripathy; X. Zhang; P. Dehal; R.H.Y. Jiang; A. Aerts; F.D. Arredondo; L. Baxter; D. Bensasson; J.L. Beynon; J. Chapman; C.M.B. Damasceno; A.E. Dorrance; D. Dou; A.W. Dickerman; I.L. Dubchak; M. Garbelotto; M. Gijzen; S.G. Gordon; F. Govers; N.J. Grunwald; W. Huang; K.L. Ivors; R.W. Jones; S. Kamoun; K. Krampis; K.H. Lamour; M.K. Lee; W.H. McDonald; M. Medina; H.J.G. Meijer; E.K. Nordberg; D.J. Maclean; M.D. Ospina-Giraldo; P.F. Morris; V. Phuntumart; N.H. Putnam; S. Rash; J.K.C. Rose; Y. Sakihama; A.A. Salamov; A. Savidor; C.F. Scheuring; B.M. Smith; B.W.S. Sobral; A. Terry; T.A. Torto-Alalibo; J. Win; Z. Xu; H. Zhang; I.V. Grigoriev; D.S. Rokhsar; J.L. Boore

doi:10.1126/science.1128796

Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis

B.M. Tyler, S. Tripathy, X. Zhang, P. Dehal, R.H.Y. Jiang, A. Aerts, F.D. Arredondo, L. Baxter, D. Bensasson, J.L. Beynon, J. Chapman, C.M.B. Damasceno, A.E. Dorrance, D. Dou, A.W. Dickerman, I.L. Dubchak, M. Garbelotto, M. Gijzen, S.G. Gordon, F. GoversN.J. Grunwald, W. Huang, K.L. Ivors, R.W. Jones, S. Kamoun, K. Krampis, K.H. Lamour, M.K. Lee, W.H. McDonald, M. Medina, H.J.G. Meijer, E.K. Nordberg, D.J. Maclean, M.D. Ospina-Giraldo, P.F. Morris, V. Phuntumart, N.H. Putnam, S. Rash, J.K.C. Rose, Y. Sakihama, A.A. Salamov, A. Savidor, C.F. Scheuring, B.M. Smith, B.W.S. Sobral, A. Terry, T.A. Torto-Alalibo, J. Win, Z. Xu, H. Zhang, I.V. Grigoriev, D.S. Rokhsar, J.L. Boore

Laboratory of Phytopathology

Research output: Contribution to journal › Article › Academic › peer-review

804 Citations (Scopus)

Abstract

Draft genome sequences have been determined for the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum. Oömycetes such as these Phytophthora species share the kingdom Stramenopila with photosynthetic algae such as diatoms, and the presence of many Phytophthora genes of probable phototroph origin supports a photosynthetic ancestry for the stramenopiles. Comparison of the two species' genomes reveals a rapid expansion and diversification of many protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors, and, in particular, a superfamily of 700 proteins with similarity to known oömycete avirulence genes

Original language	English
Pages (from-to)	1261-1266
Journal	Science
Volume	313
Issue number	5791
DOIs	https://doi.org/10.1126/science.1128796
Publication status	Published - 2006

Keywords

effector proteins
downy mildew
resistance
arabidopsis
avirulence
genes
locus
sojae
expression
virulence

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10.1126/science.1128796

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Tyler, B. M., Tripathy, S., Zhang, X., Dehal, P., Jiang, R. H. Y., Aerts, A., Arredondo, F. D., Baxter, L., Bensasson, D., Beynon, J. L., Chapman, J., Damasceno, C. M. B., Dorrance, A. E., Dou, D., Dickerman, A. W., Dubchak, I. L., Garbelotto, M., Gijzen, M., Gordon, S. G., ... Boore, J. L. (2006). Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. Science, 313(5791), 1261-1266. https://doi.org/10.1126/science.1128796

Tyler, B.M. ; Tripathy, S. ; Zhang, X. ; Dehal, P. ; Jiang, R.H.Y. ; Aerts, A. ; Arredondo, F.D. ; Baxter, L. ; Bensasson, D. ; Beynon, J.L. ; Chapman, J. ; Damasceno, C.M.B. ; Dorrance, A.E. ; Dou, D. ; Dickerman, A.W. ; Dubchak, I.L. ; Garbelotto, M. ; Gijzen, M. ; Gordon, S.G. ; Govers, F. ; Grunwald, N.J. ; Huang, W. ; Ivors, K.L. ; Jones, R.W. ; Kamoun, S. ; Krampis, K. ; Lamour, K.H. ; Lee, M.K. ; McDonald, W.H. ; Medina, M. ; Meijer, H.J.G. ; Nordberg, E.K. ; Maclean, D.J. ; Ospina-Giraldo, M.D. ; Morris, P.F. ; Phuntumart, V. ; Putnam, N.H. ; Rash, S. ; Rose, J.K.C. ; Sakihama, Y. ; Salamov, A.A. ; Savidor, A. ; Scheuring, C.F. ; Smith, B.M. ; Sobral, B.W.S. ; Terry, A. ; Torto-Alalibo, T.A. ; Win, J. ; Xu, Z. ; Zhang, H. ; Grigoriev, I.V. ; Rokhsar, D.S. ; Boore, J.L. / Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. In: Science. 2006 ; Vol. 313, No. 5791. pp. 1261-1266.

@article{849cba672ec8466a93d984e47202e990,

title = "Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis",

abstract = "Draft genome sequences have been determined for the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum. O{\"o}mycetes such as these Phytophthora species share the kingdom Stramenopila with photosynthetic algae such as diatoms, and the presence of many Phytophthora genes of probable phototroph origin supports a photosynthetic ancestry for the stramenopiles. Comparison of the two species' genomes reveals a rapid expansion and diversification of many protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors, and, in particular, a superfamily of 700 proteins with similarity to known o{\"o}mycete avirulence genes",

keywords = "effector proteins, downy mildew, resistance, arabidopsis, avirulence, genes, locus, sojae, expression, virulence",

author = "B.M. Tyler and S. Tripathy and X. Zhang and P. Dehal and R.H.Y. Jiang and A. Aerts and F.D. Arredondo and L. Baxter and D. Bensasson and J.L. Beynon and J. Chapman and C.M.B. Damasceno and A.E. Dorrance and D. Dou and A.W. Dickerman and I.L. Dubchak and M. Garbelotto and M. Gijzen and S.G. Gordon and F. Govers and N.J. Grunwald and W. Huang and K.L. Ivors and R.W. Jones and S. Kamoun and K. Krampis and K.H. Lamour and M.K. Lee and W.H. McDonald and M. Medina and H.J.G. Meijer and E.K. Nordberg and D.J. Maclean and M.D. Ospina-Giraldo and P.F. Morris and V. Phuntumart and N.H. Putnam and S. Rash and J.K.C. Rose and Y. Sakihama and A.A. Salamov and A. Savidor and C.F. Scheuring and B.M. Smith and B.W.S. Sobral and A. Terry and T.A. Torto-Alalibo and J. Win and Z. Xu and H. Zhang and I.V. Grigoriev and D.S. Rokhsar and J.L. Boore",

year = "2006",

doi = "10.1126/science.1128796",

language = "English",

volume = "313",

pages = "1261--1266",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5791",

}

Tyler, BM, Tripathy, S, Zhang, X, Dehal, P, Jiang, RHY, Aerts, A, Arredondo, FD, Baxter, L, Bensasson, D, Beynon, JL, Chapman, J, Damasceno, CMB, Dorrance, AE, Dou, D, Dickerman, AW, Dubchak, IL, Garbelotto, M, Gijzen, M, Gordon, SG, Govers, F, Grunwald, NJ, Huang, W, Ivors, KL, Jones, RW, Kamoun, S, Krampis, K, Lamour, KH, Lee, MK, McDonald, WH, Medina, M, Meijer, HJG, Nordberg, EK, Maclean, DJ, Ospina-Giraldo, MD, Morris, PF, Phuntumart, V, Putnam, NH, Rash, S, Rose, JKC, Sakihama, Y, Salamov, AA, Savidor, A, Scheuring, CF, Smith, BM, Sobral, BWS, Terry, A, Torto-Alalibo, TA, Win, J, Xu, Z, Zhang, H, Grigoriev, IV, Rokhsar, DS & Boore, JL 2006, 'Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis', Science, vol. 313, no. 5791, pp. 1261-1266. https://doi.org/10.1126/science.1128796

Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. / Tyler, B.M.; Tripathy, S.; Zhang, X.; Dehal, P.; Jiang, R.H.Y.; Aerts, A.; Arredondo, F.D.; Baxter, L.; Bensasson, D.; Beynon, J.L.; Chapman, J.; Damasceno, C.M.B.; Dorrance, A.E.; Dou, D.; Dickerman, A.W.; Dubchak, I.L.; Garbelotto, M.; Gijzen, M.; Gordon, S.G.; Govers, F.; Grunwald, N.J.; Huang, W.; Ivors, K.L.; Jones, R.W.; Kamoun, S.; Krampis, K.; Lamour, K.H.; Lee, M.K.; McDonald, W.H.; Medina, M.; Meijer, H.J.G.; Nordberg, E.K.; Maclean, D.J.; Ospina-Giraldo, M.D.; Morris, P.F.; Phuntumart, V.; Putnam, N.H.; Rash, S.; Rose, J.K.C.; Sakihama, Y.; Salamov, A.A.; Savidor, A.; Scheuring, C.F.; Smith, B.M.; Sobral, B.W.S.; Terry, A.; Torto-Alalibo, T.A.; Win, J.; Xu, Z.; Zhang, H.; Grigoriev, I.V.; Rokhsar, D.S.; Boore, J.L.

In: Science, Vol. 313, No. 5791, 2006, p. 1261-1266.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis

AU - Tyler, B.M.

AU - Tripathy, S.

AU - Zhang, X.

AU - Dehal, P.

AU - Jiang, R.H.Y.

AU - Aerts, A.

AU - Arredondo, F.D.

AU - Baxter, L.

AU - Bensasson, D.

AU - Beynon, J.L.

AU - Chapman, J.

AU - Damasceno, C.M.B.

AU - Dorrance, A.E.

AU - Dou, D.

AU - Dickerman, A.W.

AU - Dubchak, I.L.

AU - Garbelotto, M.

AU - Gijzen, M.

AU - Gordon, S.G.

AU - Govers, F.

AU - Grunwald, N.J.

AU - Huang, W.

AU - Ivors, K.L.

AU - Jones, R.W.

AU - Kamoun, S.

AU - Krampis, K.

AU - Lamour, K.H.

AU - Lee, M.K.

AU - McDonald, W.H.

AU - Medina, M.

AU - Meijer, H.J.G.

AU - Nordberg, E.K.

AU - Maclean, D.J.

AU - Ospina-Giraldo, M.D.

AU - Morris, P.F.

AU - Phuntumart, V.

AU - Putnam, N.H.

AU - Rash, S.

AU - Rose, J.K.C.

AU - Sakihama, Y.

AU - Salamov, A.A.

AU - Savidor, A.

AU - Scheuring, C.F.

AU - Smith, B.M.

AU - Sobral, B.W.S.

AU - Terry, A.

AU - Torto-Alalibo, T.A.

AU - Win, J.

AU - Xu, Z.

AU - Zhang, H.

AU - Grigoriev, I.V.

AU - Rokhsar, D.S.

AU - Boore, J.L.

PY - 2006

Y1 - 2006

N2 - Draft genome sequences have been determined for the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum. Oömycetes such as these Phytophthora species share the kingdom Stramenopila with photosynthetic algae such as diatoms, and the presence of many Phytophthora genes of probable phototroph origin supports a photosynthetic ancestry for the stramenopiles. Comparison of the two species' genomes reveals a rapid expansion and diversification of many protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors, and, in particular, a superfamily of 700 proteins with similarity to known oömycete avirulence genes

AB - Draft genome sequences have been determined for the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum. Oömycetes such as these Phytophthora species share the kingdom Stramenopila with photosynthetic algae such as diatoms, and the presence of many Phytophthora genes of probable phototroph origin supports a photosynthetic ancestry for the stramenopiles. Comparison of the two species' genomes reveals a rapid expansion and diversification of many protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors, and, in particular, a superfamily of 700 proteins with similarity to known oömycete avirulence genes

KW - effector proteins

KW - downy mildew

KW - resistance

KW - arabidopsis

KW - avirulence

KW - genes

KW - locus

KW - sojae

KW - expression

KW - virulence

U2 - 10.1126/science.1128796

DO - 10.1126/science.1128796

M3 - Article

VL - 313

SP - 1261

EP - 1266

JO - Science

JF - Science

SN - 0036-8075

IS - 5791

ER -

Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis

Abstract

Keywords

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