Abstract
Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.
| Original language | English |
|---|---|
| Title of host publication | The Principles and Practice of Q Fever: The One Health Paradigm |
| Editors | João Carlos Caetano Simoes, Sofia Ferreira Anastácio, Gabriela Jorge da Silva |
| Publisher | Nova Science Publishers |
| Pages | 91-106 |
| ISBN (Electronic) | 9781536108682 |
| ISBN (Print) | 9781536108514 |
| Publication status | Published - 2017 |
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Keywords
- Immune response
- Adaptive immunity
- Antimicrobials
- Clinical symptoms
- Innate immunity
- Pathophysiology
- Q fever fatigue syndrome
Cite this
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Physiopathology of coxiella burnetii infection and host immunologic response. / Ammerdorffer, Anne; Kuley, Runa; Roest, Hendrik-Jan.
The Principles and Practice of Q Fever: The One Health Paradigm. ed. / João Carlos Caetano Simoes; Sofia Ferreira Anastácio; Gabriela Jorge da Silva. Nova Science Publishers, 2017. p. 91-106.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Physiopathology of coxiella burnetii infection and host immunologic response
AU - Ammerdorffer, Anne
AU - Kuley, Runa
AU - Roest, Hendrik-Jan
PY - 2017
Y1 - 2017
N2 - Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.
AB - Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.
KW - Immune response
KW - Adaptive immunity
KW - Antimicrobials
KW - Clinical symptoms
KW - Innate immunity
KW - Pathophysiology
KW - Q fever fatigue syndrome
M3 - Chapter
SN - 9781536108514
SP - 91
EP - 106
BT - The Principles and Practice of Q Fever: The One Health Paradigm
A2 - Caetano Simoes, João Carlos
A2 - Ferreira Anastácio, Sofia
A2 - Jorge da Silva, Gabriela
PB - Nova Science Publishers
ER -