Physiopathology of coxiella burnetii infection and host immunologic response

Anne Ammerdorffer; Runa Kuley; Hendrik-Jan Roest

Physiopathology of coxiella burnetii infection and host immunologic response

Anne Ammerdorffer, Runa Kuley, Hendrik-Jan Roest^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.

Original language	English
Title of host publication	The Principles and Practice of Q Fever: The One Health Paradigm
Editors	João Carlos Caetano Simoes, Sofia Ferreira Anastácio, Gabriela Jorge da Silva
Publisher	Nova Science Publishers
Pages	91-106
ISBN (Electronic)	9781536108682
ISBN (Print)	9781536108514
Publication status	Published - 2017

Keywords

Immune response
Adaptive immunity
Antimicrobials
Clinical symptoms
Innate immunity
Pathophysiology
Q fever fatigue syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Physiopathology of coxiella burnetii infection and host immunologic response",

abstract = "Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.",

keywords = "Immune response, Adaptive immunity, Antimicrobials, Clinical symptoms, Innate immunity, Pathophysiology, Q fever fatigue syndrome",

author = "Anne Ammerdorffer and Runa Kuley and Hendrik-Jan Roest",

year = "2017",

language = "English",

isbn = "9781536108514",

pages = "91--106",

editor = "{Caetano Simoes}, {Jo{\~a}o Carlos} and {Ferreira Anast{\'a}cio}, Sofia and {Jorge da Silva}, Gabriela",

booktitle = "The Principles and Practice of Q Fever: The One Health Paradigm",

publisher = "Nova Science Publishers",

}

Physiopathology of coxiella burnetii infection and host immunologic response. / Ammerdorffer, Anne; Kuley, Runa; Roest, Hendrik-Jan.

The Principles and Practice of Q Fever: The One Health Paradigm. ed. / João Carlos Caetano Simoes; Sofia Ferreira Anastácio; Gabriela Jorge da Silva. Nova Science Publishers, 2017. p. 91-106.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

TY - CHAP

T1 - Physiopathology of coxiella burnetii infection and host immunologic response

AU - Ammerdorffer, Anne

AU - Kuley, Runa

AU - Roest, Hendrik-Jan

PY - 2017

Y1 - 2017

N2 - Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.

AB - Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.

KW - Immune response

KW - Adaptive immunity

KW - Antimicrobials

KW - Clinical symptoms

KW - Innate immunity

KW - Pathophysiology

KW - Q fever fatigue syndrome

M3 - Chapter

AN - SCOPUS:85020325879

SN - 9781536108514

SP - 91

EP - 106

BT - The Principles and Practice of Q Fever: The One Health Paradigm

A2 - Caetano Simoes, João Carlos

A2 - Ferreira Anastácio, Sofia

A2 - Jorge da Silva, Gabriela

PB - Nova Science Publishers

ER -

Physiopathology of coxiella burnetii infection and host immunologic response

Abstract

Keywords

UN SDGs

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