Physiopathology of coxiella burnetii infection and host immunologic response

Anne Ammerdorffer, Runa Kuley, Hendrik-Jan Roest*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.

Original languageEnglish
Title of host publicationThe Principles and Practice of Q Fever: The One Health Paradigm
EditorsJoão Carlos Caetano Simoes, Sofia Ferreira Anastácio, Gabriela Jorge da Silva
PublisherNova Science Publishers
Pages91-106
ISBN (Electronic)9781536108682
ISBN (Print)9781536108514
Publication statusPublished - 2017

Keywords

  • Immune response
  • Adaptive immunity
  • Antimicrobials
  • Clinical symptoms
  • Innate immunity
  • Pathophysiology
  • Q fever fatigue syndrome

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