Physiopathology of coxiella burnetii infection and host immunologic response

Anne Ammerdorffer, Runa Kuley, Hendrik-Jan Roest*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.

Original languageEnglish
Title of host publicationThe Principles and Practice of Q Fever: The One Health Paradigm
EditorsJoão Carlos Caetano Simoes, Sofia Ferreira Anastácio, Gabriela Jorge da Silva
PublisherNova Science Publishers
Pages91-106
ISBN (Electronic)9781536108682
ISBN (Print)9781536108514
Publication statusPublished - 2017

Fingerprint

Coxiella burnetii
Q Fever
Cattle Diseases
Bacteria
Zoonoses
Ruminants
Acute Disease
Routine Diagnostic Tests
Netherlands
Disease Outbreaks
Chronic Disease
Vaccines
Pharmacology
Delivery of Health Care
Infection

Keywords

  • Immune response
  • Adaptive immunity
  • Antimicrobials
  • Clinical symptoms
  • Innate immunity
  • Pathophysiology
  • Q fever fatigue syndrome

Cite this

Ammerdorffer, A., Kuley, R., & Roest, H-J. (2017). Physiopathology of coxiella burnetii infection and host immunologic response. In J. C. Caetano Simoes, S. Ferreira Anastácio, & G. Jorge da Silva (Eds.), The Principles and Practice of Q Fever: The One Health Paradigm (pp. 91-106). Nova Science Publishers.
Ammerdorffer, Anne ; Kuley, Runa ; Roest, Hendrik-Jan. / Physiopathology of coxiella burnetii infection and host immunologic response. The Principles and Practice of Q Fever: The One Health Paradigm. editor / João Carlos Caetano Simoes ; Sofia Ferreira Anastácio ; Gabriela Jorge da Silva. Nova Science Publishers, 2017. pp. 91-106
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editor = "{Caetano Simoes}, {Jo{\~a}o Carlos} and {Ferreira Anast{\'a}cio}, Sofia and {Jorge da Silva}, Gabriela",
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Ammerdorffer, A, Kuley, R & Roest, H-J 2017, Physiopathology of coxiella burnetii infection and host immunologic response. in JC Caetano Simoes, S Ferreira Anastácio & G Jorge da Silva (eds), The Principles and Practice of Q Fever: The One Health Paradigm. Nova Science Publishers, pp. 91-106.

Physiopathology of coxiella burnetii infection and host immunologic response. / Ammerdorffer, Anne; Kuley, Runa; Roest, Hendrik-Jan.

The Principles and Practice of Q Fever: The One Health Paradigm. ed. / João Carlos Caetano Simoes; Sofia Ferreira Anastácio; Gabriela Jorge da Silva. Nova Science Publishers, 2017. p. 91-106.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Physiopathology of coxiella burnetii infection and host immunologic response

AU - Ammerdorffer, Anne

AU - Kuley, Runa

AU - Roest, Hendrik-Jan

PY - 2017

Y1 - 2017

N2 - Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.

AB - Coxiella burnetii is an interesting example of obligate intracellular bacteria that has uniquely evolved to thrive in the harshest conditions. The bacterium can infect a wide range of host species and also exhibit a wide spectrum of clinical manifestations. C. burnetii infection can cause abortions in small ruminants, reproductive problems in cattle, and acute or chronic disease in humans. The high infectivity and zoonotic potential of C. burnetii was recently witnessed in the unprecedented Q fever outbreak in the Netherlands (2007-2010). A complete understanding of how C. burnetii can cause disease requires an appreciation of the host immune responses. This may in turn help to improve diagnostics tests, develop effective vaccines and pharmacological agents against infection, and reduce health-care burden by controlling the disease.

KW - Immune response

KW - Adaptive immunity

KW - Antimicrobials

KW - Clinical symptoms

KW - Innate immunity

KW - Pathophysiology

KW - Q fever fatigue syndrome

M3 - Chapter

SN - 9781536108514

SP - 91

EP - 106

BT - The Principles and Practice of Q Fever: The One Health Paradigm

A2 - Caetano Simoes, João Carlos

A2 - Ferreira Anastácio, Sofia

A2 - Jorge da Silva, Gabriela

PB - Nova Science Publishers

ER -

Ammerdorffer A, Kuley R, Roest H-J. Physiopathology of coxiella burnetii infection and host immunologic response. In Caetano Simoes JC, Ferreira Anastácio S, Jorge da Silva G, editors, The Principles and Practice of Q Fever: The One Health Paradigm. Nova Science Publishers. 2017. p. 91-106