Physiology, regulation and multifunctional activity of the gut wall: a rationale for multicompartmental modelling

Research output: Contribution to journalReview articleAcademicpeer-review

11 Citations (Scopus)

Abstract

A rationale is given for a modelling approach to identify the mechanisms involved in the functioning and metabolic activity of tissues in the wall of the gastrointestinal tract. Maintenance and productive functions are discussed and related to the distinct compartments of the gastrointestinal tract and the metabolic costs involved. Functions identified are: tissue turnover; tissue proliferation; ion transport; nutrient transport; secretions of digestive enzymes, mucus and immunoglobulins; production of immune cells. The major nutrients involved include glucose, amino acids and volatile fatty acids. In vivo measurements of net portal fluxes of these nutrients in pigs and ruminants are evaluated to illustrate the complexity of physiology and metabolic activity of the gastrointestinal tract. Experimental evidence indicates that high, but variable and specific, nutrient costs are involved in the functioning of the gastrointestinal tract.
Original languageEnglish
Pages (from-to)227-253
Number of pages26
JournalNutrition Research Reviews
Volume19
Issue number2
DOIs
Publication statusPublished - 2006

Fingerprint

Gastrointestinal Tract
Food
Costs and Cost Analysis
Volatile Fatty Acids
Ion Transport
Ruminants
Mucus
Immunoglobulins
Swine
Maintenance
Amino Acids
Glucose
Enzymes

Keywords

  • volatile fatty-acids
  • portal-drained viscera
  • small-intestinal disappearance
  • total intragastric infusion
  • lactating dairy-cows
  • post-stomach tissues
  • fed identical diets
  • free amino-acids
  • gastrointestinal-tract
  • nitrogenous compounds

Cite this

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title = "Physiology, regulation and multifunctional activity of the gut wall: a rationale for multicompartmental modelling",
abstract = "A rationale is given for a modelling approach to identify the mechanisms involved in the functioning and metabolic activity of tissues in the wall of the gastrointestinal tract. Maintenance and productive functions are discussed and related to the distinct compartments of the gastrointestinal tract and the metabolic costs involved. Functions identified are: tissue turnover; tissue proliferation; ion transport; nutrient transport; secretions of digestive enzymes, mucus and immunoglobulins; production of immune cells. The major nutrients involved include glucose, amino acids and volatile fatty acids. In vivo measurements of net portal fluxes of these nutrients in pigs and ruminants are evaluated to illustrate the complexity of physiology and metabolic activity of the gastrointestinal tract. Experimental evidence indicates that high, but variable and specific, nutrient costs are involved in the functioning of the gastrointestinal tract.",
keywords = "volatile fatty-acids, portal-drained viscera, small-intestinal disappearance, total intragastric infusion, lactating dairy-cows, post-stomach tissues, fed identical diets, free amino-acids, gastrointestinal-tract, nitrogenous compounds",
author = "A. Bannink and J. Dijkstra and S.J. Koopmans and Z. Mroz",
year = "2006",
doi = "10.1017/S0954422407334094",
language = "English",
volume = "19",
pages = "227--253",
journal = "Nutrition Research Reviews",
issn = "0954-4224",
publisher = "Cambridge University Press",
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Physiology, regulation and multifunctional activity of the gut wall: a rationale for multicompartmental modelling. / Bannink, A.; Dijkstra, J.; Koopmans, S.J.; Mroz, Z.

In: Nutrition Research Reviews, Vol. 19, No. 2, 2006, p. 227-253.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Physiology, regulation and multifunctional activity of the gut wall: a rationale for multicompartmental modelling

AU - Bannink, A.

AU - Dijkstra, J.

AU - Koopmans, S.J.

AU - Mroz, Z.

PY - 2006

Y1 - 2006

N2 - A rationale is given for a modelling approach to identify the mechanisms involved in the functioning and metabolic activity of tissues in the wall of the gastrointestinal tract. Maintenance and productive functions are discussed and related to the distinct compartments of the gastrointestinal tract and the metabolic costs involved. Functions identified are: tissue turnover; tissue proliferation; ion transport; nutrient transport; secretions of digestive enzymes, mucus and immunoglobulins; production of immune cells. The major nutrients involved include glucose, amino acids and volatile fatty acids. In vivo measurements of net portal fluxes of these nutrients in pigs and ruminants are evaluated to illustrate the complexity of physiology and metabolic activity of the gastrointestinal tract. Experimental evidence indicates that high, but variable and specific, nutrient costs are involved in the functioning of the gastrointestinal tract.

AB - A rationale is given for a modelling approach to identify the mechanisms involved in the functioning and metabolic activity of tissues in the wall of the gastrointestinal tract. Maintenance and productive functions are discussed and related to the distinct compartments of the gastrointestinal tract and the metabolic costs involved. Functions identified are: tissue turnover; tissue proliferation; ion transport; nutrient transport; secretions of digestive enzymes, mucus and immunoglobulins; production of immune cells. The major nutrients involved include glucose, amino acids and volatile fatty acids. In vivo measurements of net portal fluxes of these nutrients in pigs and ruminants are evaluated to illustrate the complexity of physiology and metabolic activity of the gastrointestinal tract. Experimental evidence indicates that high, but variable and specific, nutrient costs are involved in the functioning of the gastrointestinal tract.

KW - volatile fatty-acids

KW - portal-drained viscera

KW - small-intestinal disappearance

KW - total intragastric infusion

KW - lactating dairy-cows

KW - post-stomach tissues

KW - fed identical diets

KW - free amino-acids

KW - gastrointestinal-tract

KW - nitrogenous compounds

U2 - 10.1017/S0954422407334094

DO - 10.1017/S0954422407334094

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VL - 19

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JO - Nutrition Research Reviews

JF - Nutrition Research Reviews

SN - 0954-4224

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ER -