Physiologically based kinetic modelling based prediction of oral systemic bioavailability of flavonoids, their metabolites, and their biological effects

Rungnapa Boonpawa

Research output: Thesisinternal PhD, WUAcademic

Abstract

Flavonoids, abundantly present in fruits and vegetables, have been reported to exert various positive health effects based on in vitro bioassays. However, effects detected in in vitro models cannot be directly correlated to human health as most in vitro studies have been performed using flavonoid aglycones at high concentration ignoring extensive metabolism of flavonoids in the human body. To better understand positive health effects of flavonoids in humans, it is of importance to gain insight in at which form and concentration flavonoids are present in the systemic circulation after consumption. This insight can be obtained using physiologically based kinetic (PBK) computer modeling. The results obtained show that PBK modeling provides a useful additional research tool for studies on the fate of flavonoids in the human body and can reveal at what oral dose levels of flavonoids in vitro positive health effects can be expected to occur in vivo, presenting opportunities that are not easily provided by other methods.

LanguageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Rietjens, Ivonne, Promotor
  • Punt, Arjen, Co-promotor
Award date23 Jan 2017
Place of PublicationWageningen
Publisher
Print ISBNs9789463430371
DOIs
Publication statusPublished - 2017

Fingerprint

Flavonoids
Biological Availability
Health
Human Body
Biological Assay
Vegetables
Fruit
In Vitro Techniques
Research

Keywords

  • flavonoids
  • bioavailability
  • modeling
  • metabolites
  • quercetin
  • physiology
  • hesperidin

Cite this

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title = "Physiologically based kinetic modelling based prediction of oral systemic bioavailability of flavonoids, their metabolites, and their biological effects",
abstract = "Flavonoids, abundantly present in fruits and vegetables, have been reported to exert various positive health effects based on in vitro bioassays. However, effects detected in in vitro models cannot be directly correlated to human health as most in vitro studies have been performed using flavonoid aglycones at high concentration ignoring extensive metabolism of flavonoids in the human body. To better understand positive health effects of flavonoids in humans, it is of importance to gain insight in at which form and concentration flavonoids are present in the systemic circulation after consumption. This insight can be obtained using physiologically based kinetic (PBK) computer modeling. The results obtained show that PBK modeling provides a useful additional research tool for studies on the fate of flavonoids in the human body and can reveal at what oral dose levels of flavonoids in vitro positive health effects can be expected to occur in vivo, presenting opportunities that are not easily provided by other methods.",
keywords = "flavonoids, bioavailability, modeling, metabolites, quercetin, physiology, hesperidin, flavono{\"i}den, biologische beschikbaarheid, modelleren, metabolieten, quercetine, fysiologie, hesperidine",
author = "Rungnapa Boonpawa",
note = "WU thesis 6562 Includes bibliographic references. - With summary in English",
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language = "English",
isbn = "9789463430371",
publisher = "Wageningen University",
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Physiologically based kinetic modelling based prediction of oral systemic bioavailability of flavonoids, their metabolites, and their biological effects. / Boonpawa, Rungnapa.

Wageningen : Wageningen University, 2017. 180 p.

Research output: Thesisinternal PhD, WUAcademic

TY - THES

T1 - Physiologically based kinetic modelling based prediction of oral systemic bioavailability of flavonoids, their metabolites, and their biological effects

AU - Boonpawa, Rungnapa

N1 - WU thesis 6562 Includes bibliographic references. - With summary in English

PY - 2017

Y1 - 2017

N2 - Flavonoids, abundantly present in fruits and vegetables, have been reported to exert various positive health effects based on in vitro bioassays. However, effects detected in in vitro models cannot be directly correlated to human health as most in vitro studies have been performed using flavonoid aglycones at high concentration ignoring extensive metabolism of flavonoids in the human body. To better understand positive health effects of flavonoids in humans, it is of importance to gain insight in at which form and concentration flavonoids are present in the systemic circulation after consumption. This insight can be obtained using physiologically based kinetic (PBK) computer modeling. The results obtained show that PBK modeling provides a useful additional research tool for studies on the fate of flavonoids in the human body and can reveal at what oral dose levels of flavonoids in vitro positive health effects can be expected to occur in vivo, presenting opportunities that are not easily provided by other methods.

AB - Flavonoids, abundantly present in fruits and vegetables, have been reported to exert various positive health effects based on in vitro bioassays. However, effects detected in in vitro models cannot be directly correlated to human health as most in vitro studies have been performed using flavonoid aglycones at high concentration ignoring extensive metabolism of flavonoids in the human body. To better understand positive health effects of flavonoids in humans, it is of importance to gain insight in at which form and concentration flavonoids are present in the systemic circulation after consumption. This insight can be obtained using physiologically based kinetic (PBK) computer modeling. The results obtained show that PBK modeling provides a useful additional research tool for studies on the fate of flavonoids in the human body and can reveal at what oral dose levels of flavonoids in vitro positive health effects can be expected to occur in vivo, presenting opportunities that are not easily provided by other methods.

KW - flavonoids

KW - bioavailability

KW - modeling

KW - metabolites

KW - quercetin

KW - physiology

KW - hesperidin

KW - flavonoïden

KW - biologische beschikbaarheid

KW - modelleren

KW - metabolieten

KW - quercetine

KW - fysiologie

KW - hesperidine

U2 - 10.18174/400192

DO - 10.18174/400192

M3 - internal PhD, WU

SN - 9789463430371

PB - Wageningen University

CY - Wageningen

ER -