Physical and mechanical properties of thermosensitive xanthan/collagen-inspired protein composite hydrogels

Thao T.H. Pham, Frank Snijkers, Ingeborg M. Storm, Frits A. De Wolf, Martien A. Cohen Stuart, Jasper Van Der Gucht*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Functionalization of xanthan hydrogels is of interest for biomaterial applications. The authors report characterization of electrostatic complexation of xanthan with a recombinant collagen-inspired triblock protein polymer. This polymer has one charged polylysine end-block that can bind to xanthan by electrostatic interactions, and another end-block that can self-assemble into thermosensitive collagen-like triple helices; the end-blocks are connected by a neutral, hydrophilic, mostly inert random coil. The protein modifies the xanthan/protein composite hydrogels in three ways: (a) a significant increase in storage modulus, (b) thermosensitivity, and (c) a two-step strain softening in nonlinear rheology.

Original languageEnglish
Pages (from-to)125-133
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume65
Issue number3
DOIs
Publication statusPublished - 11 Feb 2016

Keywords

  • collagen-inspired protein
  • composite hydrogels
  • electrostatic interaction
  • strain-softening
  • thermosensitivity
  • Xanthan

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