Phylogenomic investigation of IncI1-I plasmids harboring blaCMY-2 and blaSHV-12 in salmonella enterica and Escherichia coli in multiple countries

Luis Ricardo Castellanos, Linda van der Graaf-Van Bloois, Pilar Donado-Godoy, Dik J. Mevius, Jaap A. Wagenaar, Joost Hordijk, Aldert L. Zomer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The objective of this study was to elucidate the genetic and evolutionary relatedness of blaCMY-2- and blaSHV-12-carrying IncI1-I plasmids. Phylogenomic analysis based on core genome alignments and gene presence/absence was performed for different IncI1-I sequence types (STs). Most IncI1-I/ST12 and IncI1-I/ ST231 plasmids had near-identical core genomes. The data suggest that widely occurring blaCMY-2-carrying IncI1-I/ST12 plasmids originate from a common ancestor. In contrast, blaSHV-12 was inserted independently into different IncI1-I/ST231-related plasmids.

LanguageEnglish
Article numbere02546-18
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number7
DOIs
Publication statusPublished - 2019

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Salmonella enterica
Plasmids
Escherichia coli
Genome
Genes

Keywords

  • Blc
  • Broiler
  • Chicken
  • DeoR
  • IS1294
  • IS26
  • ISEcp1
  • S. Heidelberg
  • Salmonella Paratyphi B var. Java
  • SugE
  • Tn1721

Cite this

Castellanos, Luis Ricardo ; van der Graaf-Van Bloois, Linda ; Donado-Godoy, Pilar ; Mevius, Dik J. ; Wagenaar, Jaap A. ; Hordijk, Joost ; Zomer, Aldert L. / Phylogenomic investigation of IncI1-I plasmids harboring blaCMY-2 and blaSHV-12 in salmonella enterica and Escherichia coli in multiple countries. In: Antimicrobial Agents and Chemotherapy. 2019 ; Vol. 63, No. 7.
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abstract = "The objective of this study was to elucidate the genetic and evolutionary relatedness of blaCMY-2- and blaSHV-12-carrying IncI1-I plasmids. Phylogenomic analysis based on core genome alignments and gene presence/absence was performed for different IncI1-I sequence types (STs). Most IncI1-I/ST12 and IncI1-I/ ST231 plasmids had near-identical core genomes. The data suggest that widely occurring blaCMY-2-carrying IncI1-I/ST12 plasmids originate from a common ancestor. In contrast, blaSHV-12 was inserted independently into different IncI1-I/ST231-related plasmids.",
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Phylogenomic investigation of IncI1-I plasmids harboring blaCMY-2 and blaSHV-12 in salmonella enterica and Escherichia coli in multiple countries. / Castellanos, Luis Ricardo; van der Graaf-Van Bloois, Linda; Donado-Godoy, Pilar; Mevius, Dik J.; Wagenaar, Jaap A.; Hordijk, Joost; Zomer, Aldert L.

In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 7, e02546-18, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Castellanos, Luis Ricardo

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AU - Donado-Godoy, Pilar

AU - Mevius, Dik J.

AU - Wagenaar, Jaap A.

AU - Hordijk, Joost

AU - Zomer, Aldert L.

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KW - Salmonella Paratyphi B var. Java

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