Phylogenetic analysis of highly pathogenic avian influenza A (H5N8) virus outbreak strains provides evidence for four separate introductions and one between-poultry farm transmission in the Netherlands, November 2014

R.J. Bouwstra, G. Koch, C.G. Heutink, F.L. Harders, A. van der Spek, A.R.W. Elbers, A. Bossers

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Abstract

Phylogenetic analysis of highly pathogenic avian influenza A(H5N8) virus strains causing outbreaks in Dutch poultry farms in 2014 provides evidence for separate introduction of the virus in four outbreaks in farms located 16–112 km from each other and for between-farm transmission between the third and fourth outbreak in farms located 550 m from each other. In addition, the analysis showed that all European and two Japanese H5N8 virus strains are very closely related and seem to originate from a calculated common ancestor, which arose between July and September 2014. Our findings suggest that the Dutch outbreak virus strain ‘Ter Aar’ and the first German outbreak strain from 2014 shared a common ancestor. In addition, the data indicate that the Dutch outbreak viruses descended from an H5N8 virus that circulated around 2009 in Asia, possibly China, and subsequently spread to South Korea and Japan and finally also to Europe. Evolution of the virus seemed to follow a parallel track in Japan and Europe, which supports the hypothesis that H5N8 virus was exchanged between migratory wild waterfowl at their breeding grounds in Siberia and from there was carried by migrating waterfowl to Europe.
LanguageEnglish
Article number21174
JournalEurosurveillance
Volume20
Issue number26
DOIs
Publication statusPublished - 2015

Fingerprint

Influenza in Birds
Influenza A virus
Poultry
Netherlands
Disease Outbreaks
Viruses
Japan
Siberia
Republic of Korea
Breeding
Farms
H5N8 Subtype Influenza A Virus
China

Keywords

  • mitochondrial-dna
  • a viruses
  • sequence
  • amplification
  • china
  • h5

Cite this

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title = "Phylogenetic analysis of highly pathogenic avian influenza A (H5N8) virus outbreak strains provides evidence for four separate introductions and one between-poultry farm transmission in the Netherlands, November 2014",
abstract = "Phylogenetic analysis of highly pathogenic avian influenza A(H5N8) virus strains causing outbreaks in Dutch poultry farms in 2014 provides evidence for separate introduction of the virus in four outbreaks in farms located 16–112 km from each other and for between-farm transmission between the third and fourth outbreak in farms located 550 m from each other. In addition, the analysis showed that all European and two Japanese H5N8 virus strains are very closely related and seem to originate from a calculated common ancestor, which arose between July and September 2014. Our findings suggest that the Dutch outbreak virus strain ‘Ter Aar’ and the first German outbreak strain from 2014 shared a common ancestor. In addition, the data indicate that the Dutch outbreak viruses descended from an H5N8 virus that circulated around 2009 in Asia, possibly China, and subsequently spread to South Korea and Japan and finally also to Europe. Evolution of the virus seemed to follow a parallel track in Japan and Europe, which supports the hypothesis that H5N8 virus was exchanged between migratory wild waterfowl at their breeding grounds in Siberia and from there was carried by migrating waterfowl to Europe.",
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Phylogenetic analysis of highly pathogenic avian influenza A (H5N8) virus outbreak strains provides evidence for four separate introductions and one between-poultry farm transmission in the Netherlands, November 2014. / Bouwstra, R.J.; Koch, G.; Heutink, C.G.; Harders, F.L.; van der Spek, A.; Elbers, A.R.W.; Bossers, A.

In: Eurosurveillance, Vol. 20, No. 26, 21174, 2015.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Koch, G.

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AU - van der Spek, A.

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AU - Bossers, A.

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