TY - CHAP
T1 - Phosphatidic acid: An electrostatic/ hydrogen-bond switch?
AU - Kooijman, Edgar Eduard
AU - Testerink, Christa
PY - 2010
Y1 - 2010
N2 - Phosphatidic acid (PA) has been shown to be an important bioactive lipid that is specifically recognized by various proteins. As such, it plays a crucial role in cellular signaling in all eukaryotes. An important determinant for PA's role in its diverse functions is its anionic headgroup that resides very close to the hydrophobic interior of the lipid bilayer. In this chapter, we describe a new model, the electrostatic/ hydrogen-bond switch that describes PA's ionization properties and its specific interaction with proteins. Furthermore, we will allude to the broader implications of the model for all phosphomonoester moieties found in biological compounds. Recent data in support of the model, as well as biological predictions arising from it, are also discussed.
AB - Phosphatidic acid (PA) has been shown to be an important bioactive lipid that is specifically recognized by various proteins. As such, it plays a crucial role in cellular signaling in all eukaryotes. An important determinant for PA's role in its diverse functions is its anionic headgroup that resides very close to the hydrophobic interior of the lipid bilayer. In this chapter, we describe a new model, the electrostatic/ hydrogen-bond switch that describes PA's ionization properties and its specific interaction with proteins. Furthermore, we will allude to the broader implications of the model for all phosphomonoester moieties found in biological compounds. Recent data in support of the model, as well as biological predictions arising from it, are also discussed.
U2 - 10.1007/978-3-642-03873-0_14
DO - 10.1007/978-3-642-03873-0_14
M3 - Chapter
AN - SCOPUS:74949105152
SN - 9783642038723
T3 - Plant Cell Monographs
SP - 203
EP - 222
BT - Lipid Signaling in Plants
A2 - Munnik, Teun
PB - Springer
ER -